Elbasvir
Elbasvir Basic information
- Product Name:
- Elbasvir
- Synonyms:
-
- Elbasvir
- Elbasvir/MK-8742
- MK-8742 Elbasvir
- MK-8742; MK8742; MK 8742
- Albasvir
- Carbamic acid, N,N'-[[(6S)-6-phenyl-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis-, C,C'-dimethyl ester
- Dimethyl ((2S,2'S)-((2S,2'S)-2,2'-(5,5'-((S)-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate
- Dimethyl ((2S,2'S)-((2S,2'S)-2,2'-(5,5'-((S)-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate
- CAS:
- 1370468-36-2
- MF:
- C49H55N9O7
- MW:
- 882.02
- Mol File:
- 1370468-36-2.mol
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Elbasvir Chemical Properties
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF: 33 mg/ml; DMSO: 20 mgm/l; Ethanol: 33 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml
- form
- A crystalline solid
- pka
- 11.22±0.46(Predicted)
- color
- White to yellow
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Elbasvir Usage And Synthesis
Uses
Elbasvir is a pharmaceutical drug that is used in the treatment of hepatitis C virus in patients with HCV genotype 1 infection. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion.
Definition
ChEBI: A complex organic heterotetracyclic compound that is a hepatitis C virus nonstructural protein 5A inhibitor used in combination with grazoprevir (under the brand name Zepatier) for treatment of chronic HCV genotypes 1 or 4 infection in adults.
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