Basic information Safety Supplier Related

Elbasvir

Basic information Safety Supplier Related

Elbasvir Basic information

Product Name:
Elbasvir
Synonyms:
  • Elbasvir
  • Elbasvir/MK-8742
  • MK-8742 Elbasvir
  • MK-8742; MK8742; MK 8742
  • Albasvir
  • Carbamic acid, N,N'-[[(6S)-6-phenyl-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis-, C,C'-dimethyl ester
  • Dimethyl ((2S,2'S)-((2S,2'S)-2,2'-(5,5'-((S)-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate
  • Dimethyl ((2S,2'S)-((2S,2'S)-2,2'-(5,5'-((S)-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate
CAS:
1370468-36-2
MF:
C49H55N9O7
MW:
882.02
Mol File:
1370468-36-2.mol
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Elbasvir Chemical Properties

Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF: 33 mg/ml; DMSO: 20 mgm/l; Ethanol: 33 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml
form 
A crystalline solid
pka
11.22±0.46(Predicted)
color 
White to yellow
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Elbasvir Usage And Synthesis

Uses

Elbasvir is a pharmaceutical drug that is used in the treatment of hepatitis C virus in patients with HCV genotype 1 infection. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion.

Definition

ChEBI: A complex organic heterotetracyclic compound that is a hepatitis C virus nonstructural protein 5A inhibitor used in combination with grazoprevir (under the brand name Zepatier) for treatment of chronic HCV genotypes 1 or 4 infection in adults.

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