TAK-063 Chemical Properties

Boiling point:

612.3±65.0 °C(Predicted)

Density 

1.37±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO:55.0(Max Conc. mg/mL);128.38(Max Conc. mM)

form 

A crystalline solid

pka

-0.34±0.12(Predicted)

TAK-063 Usage And Synthesis

Description

TAK-063 is a potent inhibitor of phosphodiesterase 10A (PDE10A; IC₅₀ = 0.3 nM). It is >15,000-fold selective for PDE10A over other PDEs and exhibits <50% inhibition at 91 receptors, ion channels, and enzymes at a concentration of 10 μM. TAK-063 (0.3 mg/kg) increases cAMP and cGMP levels by 1.3- and 2.14-fold, respectively, in the striatum of mice. It reverses hyperlocomotion induced by PCP (Item Nos. 14276 | ISO60194) with a minimum effective dose (MED) of 0.3 mg/kg, p.o., in wild-type mice but has no effect in PDE10A knockout mice at doses up to 1 mg/kg. TAK-063 also reverses hyperlocomotion induced by (+)-MK-801 (MED = 0.1 mg/kg, p.o.) but has no effect on plasma prolactin or glucose levels in rats.

TAK-063(1238697-26-1)Related Product Information

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