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BUSERELIN

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BUSERELIN Basic information

Product Name:
BUSERELIN
Synonyms:
  • (d-ser(bu(supt)(sup6)))-lh-rh(1-9)nonapeptide-ethylamide
  • (d-ser(tbu)(sup6)-ea(sup10))-lhrh
  • (d-ser(tbu)(sup6)-ea(sup10))-luteinizinghormone-releasinghormon
  • (d-ser(tbu)(sup6)-ea(sup10))-luteinizinghormone-releasinghormone
  • BUSERELIN
  • 1-9-Luteinizing hormone-releasing factor (swine), 6-[O-(1,1-dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-
  • Buserilin
  • BUSERELIN PH. EUR.
CAS:
57982-77-1
MF:
C60H86N16O13
MW:
1239.42
EINECS:
261-061-9
Product Categories:
  • hormones
  • 57982-77-1
Mol File:
57982-77-1.mol
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BUSERELIN Chemical Properties

alpha 
D20 -40.4° (c = 1 in dimethylacetamide)
Boiling point:
845.19°C (rough estimate)
Density 
1.0711 (rough estimate)
refractive index 
1.6200 (estimate)
solubility 
Sparingly soluble in water and in dilute acids.
pka
9.82±0.15(Predicted)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
InChI
InChI=1S/C60H86N16O13/c1-7-64-57(87)48-15-11-23-76(48)58(88)41(14-10-22-65-59(61)62)69-51(81)42(24-33(2)3)70-56(86)47(31-89-60(4,5)6)75-52(82)43(25-34-16-18-37(78)19-17-34)71-55(85)46(30-77)74-53(83)44(26-35-28-66-39-13-9-8-12-38(35)39)72-54(84)45(27-36-29-63-32-67-36)73-50(80)40-20-21-49(79)68-40/h8-9,12-13,16-19,28-29,32-33,40-48,66,77-78H,7,10-11,14-15,20-27,30-31H2,1-6H3,(H,63,67)(H,64,87)(H,68,79)(H,69,81)(H,70,86)(H,71,85)(H,72,84)(H,73,80)(H,74,83)(H,75,82)(H4,61,62,65)
InChIKey
CUWODFFVMXJOKD-UHFFFAOYSA-N
SMILES
N1(CCCC1C(NCC)=O)C(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(COC(C)(C)C)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C(CO)NC(=O)C(CC1C2C=CC=CC=2NC=1)NC(=O)C(CC1=CNC=N1)NC(=O)C1CCC(=O)N1
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Safety Information

HS Code 
2937190000
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BUSERELIN Usage And Synthesis

Description

Buserelin (Suprefact?) is a hormonal therapy drug used to treat advanced prostate cancer. It is a medication which is used primarily in the treatment of prostate cancer and endometriosis. It is also used for other indications such as the treatment of premenopausal breast cancer, uterine fibroids, and early puberty, in assisted reproduction for female infertility, and as a part of transgender hormone therapy. In addition, buserelin is used in veterinary medicine. The medication is typically used as a nasal spray three times per day, but is also available for use as a solution or implant for injection into fat.

Chemical Properties

White or slightly yellowish powder, hygroscopic.

Uses

Gonad-stimulating principle.

Definition

ChEBI: Buserelin is an oligopeptide.

brand name

Suprefact (Hoechst-Roussel).

Clinical Use


Treatment of advanced prostate cancer and endometriosis

Pituitary desensitisation in preparation for ovulation induction regimens using gonadotrophins

Side effects

Using too much Buserelin Injection may make you feel weak, nervous, dizzy and sick. You may also have a headache, hot flushes, stomach pain, swelling of the legs and breast pain. You may also have pain, bleeding or hardening of the skin at the site of injection

Metabolism

Metabolic inactivation by peptides occurs in the liver and kidney. The drug is also inactivated by pituitary membrane enzymes. Excreted in the urine and bile as unchanged drug and metabolites.

BUSERELINSupplier

Shenzhen JYMed Technology Co., Ltd. Gold
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755-755-26612112 15013529272;
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jymed@jymedtech.com
LGM Pharma
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1-(800)-881-8210
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Chemsky (shanghai) International Co.,Ltd
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021-50135380
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Beijing HuaMeiHuLiBiological Chemical
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010-56205725
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waley188@sohu.com
Nanjing Sunlida Biological Technology Co., Ltd.
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025-57798810
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sales@sunlidabio.com