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Elcatonin

Basic information Description References Description Background Safety Supplier Related

Elcatonin Basic information

Product Name:
Elcatonin
Synonyms:
  • (aminosubericacid1,7)-eelcalcitonin
  • 1-butanoicacid-26-l-asparticacid-27-l-valine-7-dicarbacalcitonin(salmon)
  • 29-l-alanine-
  • (L-ALPHA-AMINOSUBERIC ACID1,7)-CALCITONIN (EEL)
  • ELCATONIN
  • ELCATONIN (EEL)
  • (DES CYS1,CYCLO (SER2-ASU7))-CALCITONIN (EEL) ACETATE SALT
  • CYCLO(-SER-ASN-LEU-SER-THR-ASU)-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASP-VAL-GLY-ALA-GLY-THR-PRO-NH2
CAS:
60731-46-6
MF:
C148H244N42O47
MW:
3363.83
EINECS:
262-393-7
Mol File:
60731-46-6.mol
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Elcatonin Chemical Properties

Density 
1.49±0.1 g/cm3(Predicted)
RTECS 
HS9270000
storage temp. 
-15°C
Sequence
H-Ser-Asn-Leu-Ser-Thr-Asu-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asp-Val-Gly-Ala-Gly-Thr-Pro-OH?(Ser-Asu Lacton)
InChIKey
DDPFHDCZUJFNAT-KDIBENGQNA-N
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Elcatonin Usage And Synthesis

Description

Elcatonin (molecular formula: C148H244N42O47) is a kind of single, non-glycosylated polypeptide chain consisting of 31 amino acids. It is a calcitonin derivative, and is used as an anti-parathyroid agent. It is mainly used for remitting and eliminating the pain induced by Osteoporosis. It has several physiological effects including: (1) inhibit the absorption and autolysis of bones, thus leading to the reduction of the blood calcium level; (2) inhibit the dissolving and transferring of bone salts, further promoting the excretion of calcium and phosphorus in urine; (3) it inhibits the process of calcium, phosphorus and sodium re-absorption by renal tubules.

References

http://www.prospecbio.com/Elcatonin_7_42/
https://en.wikipedia.org/wiki/Elcatonin

Uses

Osteoporosis; Hypercalcemia; Paget’s disease

Hazard

A poison by ingestion.

Safety Profile

experimental neoplastigenic data by skin

in vivo

Elcatonin (Carbocalcitonin) (20 U/kg; s.c.; 2 d after oxaliplatin administration) attenuats oxaliplatin-induced cold and mechanical allodynia in rats[2].

Animal Model:Male Sprague-Dawley rats weighing 150-250 g (Oxaliplatin-Induced Allodynia Models)[1]
Dosage:20 U/kg
Administration:Subcutaneously; 2 d after oxaliplatin administration
Result:Attenuated oxaliplatin-induced cold in rtas.

Description

Elcatonin Synthetic is a single, non-glycosylated polypeptide chain containing 31 amino acids, having a molecular mass of 3363.2 Dalton and a Molecular formula of C148H244N42O47.

Background

Elcatonin is a Calcitonin derivative which is transformed from eel´s calcitonin by changing the S-S bond into the stable C-N bond. It inhibits the absorption and autolysis of bones, thus leads to blood calcium descending. In addition, it inhibits the bone salts dissolving and transferring and promotes the excretion of calcium and phosphorus in urine. Meanwhile, it inhibits renal tubules reabsorbing calcium, phosphorus and sodium and keeps blood calcium at normal level. It is mainly used for remitting or eliminating the pain caused by Osteoporosis.

ElcatoninSupplier

Shanghai HongTide Biotechnology Co.,Ltd. Gold
Tel
15318089928
Email
alex@hanhonggroup.com
Phygene Gold
Tel
18059081430
Email
2070812664@qq.com
Alabiochem Tech.Co., Ltd.
Tel
512-58900862 400-0707518
Email
sales@alabiochem.com
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Email
ymbetter@glbiochem.com
LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com
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