Alendronate sodium Chemical Properties

Melting point:

245°C

storage temp. 

-20°C

solubility 

water, double-distilled: 10 mg/mL

form 

solid

color 

white

Water Solubility 

Soluble in water at 10mg/ml

Merck 

14,229

Stability:

Store in freezer

InChIKey

NKENDYHBVCKCNL-UHFFFAOYSA-M

CAS DataBase Reference

121268-17-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

26-36-60

WGK Germany 

3

RTECS 

SZ6523500

HS Code 

29310095

MSDS

• Language:English Provider:SigmaAldrich

Alendronate sodium Usage And Synthesis

Chemical Properties

White Crystalline Solid

Originator

Adronat ,Neopharmed ,Italy

Uses

Alendronate sodium trihydrate is used as a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor and CD45 protein tyrosine phosphatase inhibitor. A robust inhibitor of bone resorption that induces apoptosis. Alendronate inhibits the migration and invasion of PC-3 cells (sc-2220) by interfering with the mevalonate pathway. Additionally, Alendronate, Sodium Salt is an inhibitor of CD45RC and MMP.

Uses

A bisphosphonate used as a bone reabsoption inhibitor

Uses

dopamine receptor agonist, antiParkinsonian

Uses

Inhibits bone resorption and increases bone density.

Definition

ChEBI: A hydride that is the trihydrate of alendronate sodium

Manufacturing Process

4-Amino-1-hydroxybutylidene-1,1-diphosphonic acid (ABDT).
Orthosphophorous acid (102.7 g; 1.25 moles) is introduced into a 2 liter-flask with condenser, stirrer and dropping funnel, placed on a thermostatized bath; the air is then removed with a nitrogen stream which is continued during all the reaction. The acid is melted by heating the bath to 95°C. When melting is complete, 4-aminobutyric acid (103.3; 1 mole) is added under stirring which is continued till obtaining a doughy fluid. Phosphorous trihalide (176 ml; 2 moles) is added dropwise causing the mixture to boil and evolution of gaseous hydrochloric acid which is damped by means of a suitable trap. The addition rate is adjusted so as to keep a constant reflux for about 60 minutes. When the addition is nearly over, the mixture swells, slowly hardening. Stirring is continued as long as possible, whereafter the mixture is heated for further 3 hours. Without cooling, but removing the bath, water (300 ml) is added, first slowly and then quickly. Heating and stirring are started again. Decolorizing charcoal is added and the mixture is boiled for about 5 minutes, then hotfiltered on paper and the filtrate is refluxed for 6 hours. After cooling is slowly poured in stirred methanol (1500 ml) causing thereby the separation of a white solid which collected and dried (161 g; 64.6%). The structure of ABDT is confirmed by IR spectrum, proton magnetic and nuclear magnetic resonance spectrum and elemental analysis.
The sodium salt of this acid may be prepared by adding of equivalent of sodium hydroxide.

brand name

Fosamax (Merck).

Therapeutic Function

Antiosteoporotic

General Description

Alendronate Sodium, an aminobisphosphonate compound, has been effectively used for the treatment of osteolysis, Paget′s disease and osteoporosis.

Biochem/physiol Actions

Alendronate sodium trihydrate is a bone resorption inhibitor; farnesyl diphosphate synthase inhibitor (IC50 = 460 nM); CD45 protein tyrosine phosphatase inhibitor.

Alendronate sodium(121268-17-5)Related Product Information

• Sodium hydroxide
• Etidronate disodium
• Sodium benzoate
• Sodium chlorite
• Folic acid
• Citric acid
• Glycine
• 6-Aminocaproic acid
• Ethyl 2-(Chlorosulfonyl)acetate
• Diclofenac sodium
• ALTRENOGEST
• Sodium risedronate
• Ibandronate sodium monohydrate
• Sodium bicarbonate
• Foscarnet sodium
• Sodium sulfate
• Tris(hydroxymethyl)aminomethane
• Pamidronate disodium salt