H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-OH Chemical Properties

Density 

1.38±0.1 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

Soluble in DMSO

pka

3.38±0.10(Predicted)

form 

Solid

color 

White to off-white

Sequence

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-OH Usage And Synthesis

Uses

Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC50=303 nM)[1][2].

IC 50

κ Opioid Receptor/KOR; Human Endogenous Metabolite

References

[1] Agbas A, Ahmed MS, Millington W, et al. Dynorphin A(1-8) in human placenta: amino acid sequence determined by tandem mass spectrometry. Peptides. 1995;16(4):623-627. DOI:10.1016/0196-9781(95)00013-a
[2] Ahmed MS, Zhou DH, Cavinato AG, Maulik D. Opioid binding properties of the purified kappa receptor from human placenta. Life Sci. 1989;44(13):861-871. DOI:10.1016/0024-3205(89)90586-9

H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-OH(75790-53-3)Related Product Information

• NEUROPEPTIDE Y (13-36) (PORCINE)
• NEUROPEPTIDE Y (3-36) (PORCINE)
• H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-OH
• NEUROPEPTIDE Y, PORCINE
• DYNORPHIN A (1-10) AMIDE
• H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-OH
• GASTRIC INHIBITORY POLYPEPTIDE (1-30) AMIDE (PORCINE)
• TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-NH2
• ANGIOTENSINOGEN
• NEUROPEPTIDE Y (2-36) (PORCINE)
• Glycylglycyl-L-isoleucine
• Glycyl-glycyl-L-valine
• H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-OH
• H-ARG-VAL-OH ACETATE SALT
• LEU-ENKEPHALIN AMIDE
• H-BETA-ALA-ILE-OH
• DES-TYR1-LEUCINE ENKEPHALINAMIDE ACETATE SALT
• ([125I]-TYR)-DYNORPHIN A (1-8)