LEU-ENKEPHALIN AMIDE
LEU-ENKEPHALIN AMIDE Basic information
- Product Name:
- LEU-ENKEPHALIN AMIDE
- Synonyms:
-
- ALPHA-NEOENDORPHIN (1-5) AMIDE
- leucine enkephalinamide acetate
- DYNORPHIN A (1-5) AMIDE
- DYNORPHIN A (1-5) AMIDE ACETATE SALT
- H-TYR-GLY-GLY-PHE-LEU-NH2
- H-TYR-GLY-GLY-PHE-LEU-NH2 ACETATE SALT
- LEU-ENKEPHALIN NH2
- LEU-ENKEPHALIN AMIDE
- CAS:
- 60117-24-0
- MF:
- C28H38N6O6
- MW:
- 554.64
- Mol File:
- 60117-24-0.mol
LEU-ENKEPHALIN AMIDE Chemical Properties
- Melting point:
- 123-126 °C
- Boiling point:
- 1012.8±65.0 °C(Predicted)
- Density
- 1.254±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Soluble in DMSO
- pka
- 9.97±0.15(Predicted)
- form
- Solid
- color
- White to off-white
- Sequence
- Tyr-Gly-Gly-Phe-Leu-NH2
LEU-ENKEPHALIN AMIDE Usage And Synthesis
Uses
[Leu5]-Enkephalin, amide is a δ opioid receptor agonist.
in vivo
Levels of [Leu5]-Enkephalin are significantly increased in the nucleus raphe magnus (NRM) of rats 2 weeks after the injection of complete Freund's adjuvant (CFA) (1.02±0.2 pmol/mg protein) as compared with saline-treated rats (0.49±0.04 pmol/mg protein; p<0.01). Tissue levels of [Leu5]-Enkephalin are uniformly increased in the caudal ventrolateral periaqueductal gray (PAG) 4 hr (1.15±0.25 pmol/mg protein), 4 d (1.16±0.18 pmol/mg protein), and 2 weeks (1.18±0.17 pmol/mg protein) after the injection of CFA as compared with saline-treated rats (0.55±0.03 pmol/mg protein; p<0.05, all times). A smaller increase in the levels of [Leu5]-Enkephalin occurred in the rostral aspect of the ventrolateral PAG at all time points. Finally, levels of [Leu5]-Enkephalin are also increased in the contralateral microcellular tegmental nucleus 4 d after the injection of CFA (0.53±0.04 pmol/mg protein) compared with levels in saline-treated rats (0.38±0.02 pmol/mg protein; p<0.05)[1].
References
[1] Hurley RW, et al. Contribution of endogenous enkephalins to the enhanced analgesic effects of supraspinal mu opioid receptor agonists after inflammatory injury. J Neurosci. 2001 Apr 1;21(7):2536-45. DOI:10.1523/JNEUROSCI.21-07-02536.2001
[2] Kennedy C, et al. [Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon. Br J Pharmacol. 1987 Oct;92(2):291-8. DOI:10.1111/j.1476-5381.1987.tb11323.x
LEU-ENKEPHALIN AMIDESupplier
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LEU-ENKEPHALIN AMIDE(60117-24-0)Related Product Information
- CYT-1010
- MM 54
- H-ALA-ARG-LEU-ASP-VAL-ALA-SER-GLU-PHE-ARG-LYS-LYS-TRP-ASN-LYS-TRP-ALA-LEU-SER-ARG-NH2
- PACAP (1-27), human, ovine, rat (TFA)
- BAY 55-9837
- H-ALA-VAL-SER-GLU-HIS-GLN-LEU-LEU-HIS-ASP-LYS-GLY-LYS-SER-ILE-GLN-ASP-LEU-ARG-ARG-ARG-PHE-PHE-LEU-HIS-HIS-LEU-ILE-ALA-GLU-ILE-HIS-THR-ALA-OH
- Met-enkephalinamide
- Dynorphin A (1-13)
- TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-TRP-ASP-ASN-GLN-NH2
- H-TYR-GLY-GLY-PHE-LEU-D-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-OH
- LEU-ENKEPHALIN-ARG-PHE
- LEU-ENKEPHALIN-ARG
- H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-OH
- DYNORPHIN B
- TYR-GLY-GLY-PHE-LEU-ARG-LYS-ARG
- DYNORPHIN A (1-10) AMIDE
- H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-D-ARG-ARG-PRO-LYS-LEU-LYS-OH
- H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-OH