Basic information Safety Supplier Related

MM 54

Basic information Safety Supplier Related

MM 54 Basic information

Product Name:
MM 54
Synonyms:
  • MM 54
  • L-Cysteine, L-cysteinyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-cysteinyl-L-lysyl-L-histidyl-L-cysteinyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-, cyclic (1→6),(9→14)-bis(disulfide)
  • Cys9-Cys14)
  • H-Cys-Arg-Pro-Arg-Leu-Cys-Lys-His-Cys-Arg-Pro-Arg-Leu-Cys-OH(Disulfide bridge：Cys1-Cys6
  • MM 54 （TFA salt）
CAS:
1313027-43-8
MF:
C70H121N29O15S4
MW:
1737.17
Mol File:
1313027-43-8.mol
More
Less

MM 54 Chemical Properties

Density 
1.59±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
2.95±0.70(Predicted)
color 
White to off-white
Water Solubility 
Soluble to 2 mg/ml in water
Sequence
Cys-Arg-Pro-Arg-Leu-Cys-Lys-His-Cys-Arg-Pro-Arg-Leu-Cys (Disulfide bridge:Cys1-Cys6; Cys9-Cys14)
More
Less

MM 54 Usage And Synthesis

Uses

MM 54 (compound 5) is a competitive antagonist at APJ, with an IC50 of 93 nM. MM 54 behaves as a potent and selective inhibitor of apelin binding and APLNR activation[1][2].

in vivo

MM 54 (2 mg/kg, ip, bi-weekly for 4 weeks) possesses anti-tumor activity in glioblastoma models with no obvious toxicity[2].

Animal Model:Tumour-bearing nude-mice[2].
Dosage:2 mg/kg.
Administration:Intraperitoneal injection, bi-weekly for 4 weeks.
Result:Reduced tumor progression (glioblastoma).

storage

Store at -20°C

References

[1] N J Maximilian Macaluso, et al. Discovery of a competitive apelin receptor (APJ) antagonist. ChemMedChem. 2011 Jun 6;6(6):1017-23. DOI:10.1002/cmdc.201100069
[2] Elizabeth Harford-Wright, et al. Pharmacological targeting of apelin impairs glioblastoma growth. Brain. 2017 Nov 1;140(11):2939-2954. DOI:10.1093/brain/awx253

MM 54Supplier

Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Email
info@chemlin.com.cn
Creative Peptides
Tel
Email
info@creative-peptides.com
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Email
Sales@ATKchemical.com
Chengdu Youngshe Chemical Co., Ltd.
Tel
+86-17380623303
Email
Caroline@youngshechem.com
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Email
Eric@peptidego.com
More
Less

MM 54(1313027-43-8)Related Product Information