PDZ1 DOMAIN INHIBITOR PEPTIDE Chemical Properties

Boiling point:

1304.2±65.0 °C(Predicted)

Density 

1.32±0.1 g/cm3(Predicted)

storage temp. 

Desiccate at -20°C

solubility 

Soluble to 1 mg/ml in 5% acetonitrile / Water and to 4 mg/ml in DMSO

pka

3.36±0.10(Predicted)

form 

Solid

color 

White to off-white

Sequence

Tyr-Lys-Lys-Thr-Glu-Ala-Val (Lactam bridge:Lys3-Glu5)

PDZ1 DOMAIN INHIBITOR PEPTIDE Usage And Synthesis

Uses

PDZ1 Domain inhibitor peptide, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain[1].

References

[1] Andrea Piserchio, et al. Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chem Biol. 2004 Apr;11(4):469-73. DOI:10.1016/j.chembiol.2004.03.013

PDZ1 DOMAIN INHIBITOR PEPTIDE(1315378-73-4)Related Product Information

• TCS 184
• D-Trp(34) neuropeptide Y
• AC-LEU-ASP-GLN-TRP-PHE-GLY-NH2
• PTH (1-84) (HUMAN)
• Compstatin control peptide
• ECHISTATIN
• GATX2
• APETx2
• ω-Agatoxin TK
• Cyclo[L-α-aspartyl-D-phenylalanyl-L-lysyl-N5-[[[(2,3-dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-L-ornithylglycyl], 1,1-dimethylethyl ester
• MM 54
• (Gly1,Ser3·22,Gln4·34,Thr6,Arg19,Tyr21,Ala23·31,Aib32)-Pancreatic Polypeptide (human)
• Vosoritide acetate