ChemicalBook > CAS DataBase List > MM 54
MM 54
- Product Name
- MM 54
- CAS No.
- 1313027-43-8
- Chemical Name
- MM 54
- Synonyms
- MM 54;Cys9-Cys14);MM 54 （TFA salt）;H-Cys-Arg-Pro-Arg-Leu-Cys-Lys-His-Cys-Arg-Pro-Arg-Leu-Cys-OH(Disulfide bridge：Cys1-Cys6;L-Cysteine, L-cysteinyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-cysteinyl-L-lysyl-L-histidyl-L-cysteinyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-, cyclic (1→6),(9→14)-bis(disulfide)
- CBNumber
- CB34796573
- Molecular Formula
- C70H121N29O15S4
- Formula Weight
- 1737.17
- MOL File
- 1313027-43-8.mol
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MM 54 Property
- Density
- 1.59±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 2.95±0.70(Predicted)
- color
- White to off-white
- Water Solubility
- Soluble to 2 mg/ml in water
- Sequence
- Cys-Arg-Pro-Arg-Leu-Cys-Lys-His-Cys-Arg-Pro-Arg-Leu-Cys (Disulfide bridge:Cys1-Cys6; Cys9-Cys14)
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N-Bromosuccinimide Price
Tocris
- Product number
- 5992
- Product name
- MM54
- Packaging
- 1
- Price
- $283
- Updated
- 2021/12/16
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MM 54 Chemical Properties,Usage,Production
Uses
MM 54 (compound 5) is a competitive antagonist at APJ, with an IC50 of 93 nM. MM 54 behaves as a potent and selective inhibitor of apelin binding and APLNR activation[1][2].
in vivo
MM 54 (2 mg/kg, ip, bi-weekly for 4 weeks) possesses anti-tumor activity in glioblastoma models with no obvious toxicity[2].
| Animal Model: | Tumour-bearing nude-mice[2]. |
| Dosage: | 2 mg/kg. |
| Administration: | Intraperitoneal injection, bi-weekly for 4 weeks. |
| Result: | Reduced tumor progression (glioblastoma). |
storage
Store at -20°C
References
[1] N J Maximilian Macaluso, et al. Discovery of a competitive apelin receptor (APJ) antagonist. ChemMedChem. 2011 Jun 6;6(6):1017-23. DOI:10.1002/cmdc.201100069
[2] Elizabeth Harford-Wright, et al. Pharmacological targeting of apelin impairs glioblastoma growth. Brain. 2017 Nov 1;140(11):2939-2954. DOI:10.1093/brain/awx253
MM 54 Preparation Products And Raw materials
Raw materials
Preparation Products
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