ECHISTATIN

Product Name: ECHISTATIN
CAS No.: 154303-05-6
Chemical Name: ECHISTATIN
Synonyms: Cys8-Cys37;Cys7-Cys32;Cys20-Cys39);Echistatin α1;ECHISTATIN,A1 ISOFORM;Echistatin, α1 isoform;Echistatin, α1 isoform;Echistatin,α1 isoform，TFA salt;M.W. 5417.05 C217H341N71O74S9 (Disulfide bonds between Cys2 and Cys11/Cys7 and Cys32/ Cys8 and Cys37/Cys20 and Cys39);H-Glu-Cys-Glu-Ser-Gly-Pro-Cys-Cys-Arg-Asn-Cys-Lys-Phe-Leu-Lys-Glu-Gly-Thr-Ile-Cys-Lys-Arg-Ala-Arg-Gly-Asp-Asp-Met-Asp-Asp-Tyr-Cys-Asn-Gly-Lys-Thr-Cys-Asp-Cys-Pro-Arg-Asn-Pro-His-Lys-Gly-Pro-Ala-Thr-OH
CBNumber: CB4973021
Molecular Formula: C217H341N71O74S9
Formula Weight: 5417.04574
MOL File: 154303-05-6.mol

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ECHISTATIN Property

storage temp.: -20°C
form: Powder
Water Solubility: Soluble to 1 mg/ml in water

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B5391
Product name: Echistatin,α1isoform
Packaging: 100ug
Price: $528
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002517
Product name: ECHISTATIN
Purity: 95.00%
Packaging: 0.1MG
Price: $800.76
Updated: 2021/12/16

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ECHISTATIN Chemical Properties,Usage,Production

Uses

Echistatin has been used:

as an inhibitor of integrin function to study the role of microfibril-associated glycoprotein-1 (Magp1) in the morphogenesis of vascular structures
for the preparation of microbubbles targeted to αvβ3 integrins in tumor angiogenesis imaging
as a conjugate to αvβ3 in flow cytometric binding studies

General Description

Echistatin is a single chain 49 amino acid residue protein, which prevents the aggregation of platelets. It has an isoelectric point (pI) of 8.3 and a molecular weight of 5400. This peptide is present in the venom of Echis carinatus, which is a saw-scaled viper. It contains the arginine-glycine-aspartic (RGD) acid sequence, which is present in proteins that bind to glycoprotein IIb/IIIa complex. It shares the proline-arginine-asparagine-proline sequence with the Aα chain of human fibrinogen. This protein is a member of disintegrin family, which prevents cell adhesion. With regards to molecular weight, echistatins are the smallest member of disintegrin family, and contains four isoforms called, α1, α2, β and γ.

Biochem/physiol Actions

Echistatin is a disintegrin, which prevents the aggregation of platelets. They interact with and prevent the binding of fibrinogen to their receptors on the membrane of platelets. It also inhibits platelet aggregation mediated by epinephrine, thrombin, collagen, or platelet-activating factor. Studies in isolated osteoclasts show that this peptide inhibits bone resorption by osteoclasts, most probably by damaging adhesion structures.

storage

Store at -20°C

ECHISTATIN Preparation Products And Raw materials

Raw materials

Preparation Products

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ECHISTATIN Suppliers

China 36 Germany 1 Switzerland 1 United Kingdom 1 United States 7 USA 1 Global 47

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Creative Peptides

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Email: info@creative-peptides.com
Country: United States
ProdList: 6083
Advantage: 56

Chengdu Youngshe Chemical Co., Ltd.

Tel: +86-17380623303 +86-17380623303
Fax: 028-62328193
Email: Caroline@youngshechem.com
Country: China
ProdList: 4812
Advantage: 58

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Fax: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 6968
Advantage: 58

BOC Sciences

Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Country: United States
ProdList: 19741
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Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30238
Advantage: 58

154303-05-6, ECHISTATINRelated Search:

TCS 184 D-Trp(34) neuropeptide Y AC-LEU-ASP-GLN-TRP-PHE-GLY-NH2 PTH (1-84) (HUMAN) Compstatin control peptide GATX2 APETx2 ω-Agatoxin TK Cyclo[L-α-aspartyl-D-phenylalanyl-L-lysyl-N5-[[[(2,3-dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-L-ornithylglycyl], 1,1-dimethylethyl ester MM 54 (Gly1,Ser3·22,Gln4·34,Thr6,Arg19,Tyr21,Ala23·31,Aib32)-Pancreatic Polypeptide (human) Vosoritide acetate PDZ1 DOMAIN INHIBITOR PEPTIDE

M.W. 5417.05 C217H341N71O74S9 (Disulfide bonds between Cys2 and Cys11/Cys7 and Cys32/ Cys8 and Cys37/Cys20 and Cys39)

Echistatin, α1 isoform

H-Glu-Cys-Glu-Ser-Gly-Pro-Cys-Cys-Arg-Asn-Cys-Lys-Phe-Leu-Lys-Glu-Gly-Thr-Ile-Cys-Lys-Arg-Ala-Arg-Gly-Asp-Asp-Met-Asp-Asp-Tyr-Cys-Asn-Gly-Lys-Thr-Cys-Asp-Cys-Pro-Arg-Asn-Pro-His-Lys-Gly-Pro-Ala-Thr-OH

ECHISTATIN,A1 ISOFORM

Cys20-Cys39)

Cys7-Cys32

Cys8-Cys37

H-Glu-Cys-Glu-Ser-Gly-Pro-Cys-Cys-Arg-Asn-Cys-Lys-Phe-Leu-Lys-Glu-Gly-Thr-Ile-Cys-Lys-Arg-Ala-Arg-Gly-Asp-Asp-Met-Asp-Asp-Tyr-Cys-Asn-Gly-Lys-Thr-Cys-Asp-Cys-Pro-Arg-Asn-Pro-His-Lys-Gly-Pro-Ala-Thr-OH(Disulfide bridge：Cys2-Cys11

Echistatin, α1 isoform

Echistatin,α1 isoform，TFA salt

Echistatin α1

154303-05-6

Fibrinogen/Thrombin