Dynorphin A (1-13) Chemical Properties

Density 

1.39±0.1 g/cm3(Predicted)

RTECS 

JV7436666

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

pka

3.31±0.10(Predicted)

form 

Solid

color 

White to off-white

Water Solubility 

Water: ≥ 60 mg/mL (37.41 mM)

Sequence

H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH

Cosmetics Ingredients Functions

ANTI-SEBUM
SKIN PROTECTING

InChIKey

OVVIBUHLQIYUEU-JASZZEBFNA-N

Safety Information

WGK Germany 

3

HS Code 

2933998090

MSDS

• Language:English Provider:SigmaAldrich

Dynorphin A (1-13) Usage And Synthesis

Description

Dynorphin A(1-13), a tridecapeptide of the endogenous opioid peptides, has modest effects in reducing mild opiate withdrawal in humans. Previous studies revealed that dynorphin also potentiates the analgesic effect of morphine in morphine-tolerant rats and mice. The therapeutic potential of dynorphin A(1-13) is limited due to extensive metabolism by human metabolic enzymes resulting in an in vivo half-life of less than one minute. Chemical modifications of dynorphin A(1-13), such as N-methylation of Tyr1 and amidation of the C-terminus have been shown to be effective in protecting against the proteolytic enzymes in human plasma^[1].

Uses

Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations.

Application

Dynorphin A (1-13) has been used as a test compound in the field asymmetric waveform ion mobility spectrometry coupled to mass spectrometry (FAIMS/IMS/MS).

Biochem/physiol Actions

Dynorphin A (1-13), a bioactive product of dynorphin A displays interaction with N-methyl- D-aspartate (NMDA) as well as with opioid receptors. It elevates intracellular calcium [Ca²⁺]i level and contributes to the loss of neurons affecting neuronal viability.

in vivo

IC 50

κ Opioid Receptor/KOR

References

[1] B BRUGOS; G H. Metabolism of dynorphin A(1-13).[J]. Pharmazie, 2004.

Dynorphin A (1-13)(72957-38-1)Related Product Information

• DYNORPHIN B (1-13)
• H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH
• LEU-ENKEPHALIN-ARG
• dynorphin B (1-29)
• DYNORPHIN B (1-9)
• TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-TRP-ASP-ASN-GLN-NH2
• Dynorphin A (1-13)
• L-LEUCYL-L-ALANINE
• (D-ARG6)-DYNORPHIN A (1-13),[D-ARG6]-DYNORPHIN A (1-13), PORCINE
• DYNORPHIN A (2-13), PORCINE,DYNORPHIN A (2-13)
• dynorphin amide (1-13), Ala(2)-(5-F-Phe)(4)-
• [D-ALA2]-DYNORPHIN A (1-13) AMIDE,[DALA2] DYNORPHIN A (1-13), AMIDE, PORCINE
• [DALA2, DARG6] DYNORPHIN A, (1-13), PORCINE,(D-ALA2,D-ARG6)-DYNORPHIN A (1-13)
• (ARG11,13)-DYNORPHIN A (1-13)-GLY-NH-(CH2)5-NH2,(ARG11,13)-DYNORPHIN A (1-13)-GLY-5-AMINO-PENTYLAMIDE
• DYNORPHIN A (1-11) AMIDE
• DYNORPHIN A (1-10) AMIDE
• H-LYS-LEU-NH2
• LEU-ENKEPHALIN AMIDE