H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH Chemical Properties

storage temp. 

-15°C

solubility 

Soluble in DMSO

Sequence

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro

H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH Usage And Synthesis

Uses

Dynorphin A (1-10) an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC50 of 42.0 μM.

IC 50

NMDA Receptor; κ Opioid Receptor/KOR

References

[1] Paterlini G, et al. Molecular simulation of dynorphin A-(1-10) binding to extracellular loop 2 of the kappa-opioidreceptor. A model for receptor activation. J Med Chem. 1997 Sep 26;40(20):3254-62. DOI:10.1021/jm970252j
[2] Chen L, et al. Dynorphin block of N-methyl-D-aspartate channels increases with the peptide length. J Pharmacol Exp Ther. 1998 Mar;284(3):826-31. PMID:9495839

H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH(79994-24-4)Related Product Information

• RIMORPHIN
• TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-TRP-ASP-ASN-GLN-NH2
• Dynorphin A (1-13)
• DYNORPHIN B (1-9)
• dynorphin B (1-29)
• LEU-ENKEPHALIN-ARG
• H-ALA-ALA-PRO-OH
• DES-TYR1-LEUCINE ENKEPHALINAMIDE ACETATE SALT
• H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH
• LEU-ENKEPHALIN AMIDE
• H-VAL-GLY-GLY-OH