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Dynorphin A (1-13)

Product Name
Dynorphin A (1-13)
CAS No.
72957-38-1
Chemical Name
Dynorphin A (1-13)
Synonyms
Dyn(1-13);YGGFLRRIRPKLK;DYNORPHIN 1-13;ynorphin A (1-13);DYNORPHIN A (1-13);sh-Oligopeptide-71;Dynorphin A1-13【pig】;Dynorphin A(1-13)【pig】;Dynorphin A(1-13)【rat】;DYNORPHIN A(HUMAN, 1-13)
CBNumber
CB6699152
Molecular Formula
C75H126N24O15
Formula Weight
1603.96
MOL File
72957-38-1.mol
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Dynorphin A (1-13) Property

Density 
1.39±0.1 g/cm3(Predicted)
RTECS 
JV7436666
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
pka
3.31±0.10(Predicted)
form 
Solid
color 
White to off-white
Water Solubility 
Water: ≥ 60 mg/mL (37.41 mM)
Sequence
H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH
Cosmetics Ingredients Functions
ANTI-SEBUM
SKIN PROTECTING
InChIKey
OVVIBUHLQIYUEU-JASZZEBFNA-N
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Safety

WGK Germany 
3
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D7017
Product name
Dynorphin A Porcine Fragment 1-13
Purity
≥97% (HPLC)
Packaging
1mg
Price
$210
Updated
2026/04/30
Chem-Impex
Product number
11101
Product name
Dynorphin A (1-13)
Packaging
1MG
Price
$91.6
Updated
2026/05/19
Chem-Impex
Product number
11101
Product name
Dynorphin A (1-13)
Packaging
5MG
Price
$349.5
Updated
2026/05/19
DC Chemicals
Product number
DC22520
Product name
Porcine dynorphin A(1-13)
Purity
>98%
Packaging
5mg
Price
$120
Updated
2026/05/24
DC Chemicals
Product number
DC22520
Product name
Porcine dynorphin A(1-13)
Purity
>98%
Packaging
10mg
Price
$192
Updated
2026/05/24
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Dynorphin A (1-13) Chemical Properties,Usage,Production

Description

Dynorphin A(1-13), a tridecapeptide of the endogenous opioid peptides, has modest effects in reducing mild opiate withdrawal in humans. Previous studies revealed that dynorphin also potentiates the analgesic effect of morphine in morphine-tolerant rats and mice. The therapeutic potential of dynorphin A(1-13) is limited due to extensive metabolism by human metabolic enzymes resulting in an in vivo half-life of less than one minute. Chemical modifications of dynorphin A(1-13), such as N-methylation of Tyr1 and amidation of the C-terminus have been shown to be effective in protecting against the proteolytic enzymes in human plasma[1].

Uses

Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations.

Application

Dynorphin A (1-13) has been used as a test compound in the field asymmetric waveform ion mobility spectrometry coupled to mass spectrometry (FAIMS/IMS/MS).

Biochem/physiol Actions

Dynorphin A (1-13), a bioactive product of dynorphin A displays interaction with N-methyl- D-aspartate (NMDA) as well as with opioid receptors. It elevates intracellular calcium [Ca2+]i level and contributes to the loss of neurons affecting neuronal viability.

in vivo

Dynorphin A (1-13) exposure (33 μM) causes a significant loss in neuronal viability at 4 h with a visible destruction in neuronal morphology seen at 16 h. Exposure to dynorphin A (1-13) causes acute increases in [Ca2+]i in individual neurons similar to increases seen with acute NMDA treatment. Continuous exposure to dynorphin A (1-13) (100 μM) causes a significant loss of neurons over time[1].

IC 50

κ Opioid Receptor/KOR

References

[1] B BRUGOS; G H. Metabolism of dynorphin A(1-13).[J]. Pharmazie, 2004.

Dynorphin A (1-13) Preparation Products And Raw materials

Raw materials

Preparation Products

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Dynorphin A (1-13) Suppliers

China 153 France 1 Germany 3 India 1 Japan 3 Switzerland 1 United States 22 USA 1 Global 185
Alabiochem Tech.Co., Ltd.
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512-58900862 400-0707518
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0086-512-56765862
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sales@alabiochem.com
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Wuxi Zhongkun Biochemical Technology Co., Ltd.
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NINGBO INNO PHARMCHEM CO.,LTD.
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View Lastest Price from Dynorphin A (1-13) manufacturers

Chengdu Shengnuo Biopharm Co.,Ltd
Product
Tridecapeptide-1 72957-38-1
Price
US $500.00-500.00/kg
Min. Order
1kg
Purity
≥99.00%
Supply Ability
1000000
Release date
2025-10-10
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Dynorphin A (1-13) 72957-38-1
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-07-24
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Dynorphin A (1-13) 72957-38-1
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%min
Supply Ability
1000g
Release date
2025-07-10

72957-38-1, Dynorphin A (1-13)Related Search:

DYNORPHIN B (1-13) H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH LEU-ENKEPHALIN-ARG dynorphin B (1-29) DYNORPHIN B (1-9) TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-TRP-ASP-ASN-GLN-NH2 Dynorphin A (1-13) L-LEUCYL-L-ALANINE (D-ARG6)-DYNORPHIN A (1-13),[D-ARG6]-DYNORPHIN A (1-13), PORCINE DYNORPHIN A (2-13), PORCINE,DYNORPHIN A (2-13) dynorphin amide (1-13), Ala(2)-(5-F-Phe)(4)- [D-ALA2]-DYNORPHIN A (1-13) AMIDE,[DALA2] DYNORPHIN A (1-13), AMIDE, PORCINE [DALA2, DARG6] DYNORPHIN A, (1-13), PORCINE,(D-ALA2,D-ARG6)-DYNORPHIN A (1-13) (ARG11,13)-DYNORPHIN A (1-13)-GLY-NH-(CH2)5-NH2,(ARG11,13)-DYNORPHIN A (1-13)-GLY-5-AMINO-PENTYLAMIDE DYNORPHIN A (1-11) AMIDE DYNORPHIN A (1-10) AMIDE H-LYS-LEU-NH2 LEU-ENKEPHALIN AMIDE

  • TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS
  • TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS 5ACOH 6H2O
  • TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS PORCINE
  • YGGFLRRIRPKLK
  • L-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS
  • DYNORPHIN A PORCINE FRAGMENT 1-13
  • DYNORPHIN A(HUMAN, 1-13)
  • DYNORPHIN A (HUMAN, 1-13) (PORCINE, RAT, BOVINE)
  • DYNORPHIN A (HUMAN, 1-13) (PORCINE, RAT, BOVINE) 5ACOH 6H2O
  • DYNORPHIN A (1-13)
  • DYNORPHIN A (1-13), PORCINE
  • DYNORPHIN 1-13
  • H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-OH
  • DYNORPHIN A (2-13) SYNTHETIC >97% OPIOID AGONIST
  • DYNORPHIN A (1-13) SYNTHETIC >97% OPIOID AGONIST
  • Dynorphin A (1-13) (human, porcine)
  • Porcine dynorphin A(1-13)
  • H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH acetate salt
  • dynorphin A, porcine, fragment 1-13 acetate
  • Dyn(1-13)
  • Dynorphin A(1-13)【pig】
  • Dynorphin A(1-13)【rat】
  • Dynorphin A1-13【pig】
  • Dynorphin (1-17), Dynorphin (1-14)
  • Dynphin A (1-13) Acetate
  • Porcine dynorphin A(1-13),Dynorphin A Porcine Fragment 1-13, BR
  • 1-13-Dynorphin A (swine)
  • Dynorphin A (1-13) USP/EP/BP
  • Dynorphin (1-17), Dynorphin (1-13)(net)
  • 1-13-Dynorphin A acetate salt
  • Dynorphin A (1-13), porcine Acetate
  • sh-Oligopeptide-71
  • Dynorphin A (porcine 1-13) - acetate salt
  • ynorphin A (1-13)
  • 72957-38-1
  • C75H126N24O15
  • Dynorphins
  • Peptides
  • Opioid Peptides
  • BioChemical
  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • Opioid receptor and opioid-like receptor
  • peptide
  • DynorphinsPeptides for Cell Biology
  • Dynorphins
  • Neuropeptides
  • Opioid Peptides