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Dynorphin A (1-13)

Product Name
Dynorphin A (1-13)
CAS No.
72957-38-1
Chemical Name
Dynorphin A (1-13)
Synonyms
Dyn(1-13);YGGFLRRIRPKLK;DYNORPHIN 1-13;DYNORPHIN A (1-13);sh-Oligopeptide-71;Dynorphin A1-13【pig】;Dynorphin A(1-13)【pig】;Dynorphin A(1-13)【rat】;DYNORPHIN A(HUMAN, 1-13);Dynphin A (1-13) Acetate
CBNumber
CB6699152
Molecular Formula
C75H126N24O15
Formula Weight
1603.95
MOL File
72957-38-1.mol
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Dynorphin A (1-13) Property

Density 
1.39±0.1 g/cm3(Predicted)
RTECS 
JV7436666
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
pka
3.31±0.10(Predicted)
form 
Solid
color 
White to off-white
Water Solubility 
Water: ≥ 60 mg/mL (37.41 mM)
Sequence
H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH
InChI
InChI=1/C75H126N24O15/c1-7-45(6)61(70(111)94-53(25-17-35-87-75(83)84)71(112)99-36-18-26-58(99)69(110)93-50(21-11-13-31-76)64(105)96-56(38-44(4)5)67(108)95-54(72(113)114)22-12-14-32-77)98-65(106)52(24-16-34-86-74(81)82)91-63(104)51(23-15-33-85-73(79)80)92-66(107)55(37-43(2)3)97-68(109)57(40-46-19-9-8-10-20-46)90-60(102)42-88-59(101)41-89-62(103)49(78)39-47-27-29-48(100)30-28-47/h8-10,19-20,27-30,43-45,49-58,61,100H,7,11-18,21-26,31-42,76-78H2,1-6H3,(H,88,101)(H,89,103)(H,90,102)(H,91,104)(H,92,107)(H,93,110)(H,94,111)(H,95,108)(H,96,105)(H,97,109)(H,98,106)(H,113,114)(H4,79,80,85)(H4,81,82,86)(H4,83,84,87)/t45-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,61-/s3
InChIKey
OVVIBUHLQIYUEU-JASZZEBFNA-N
SMILES
N1(CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)O)CCCCN)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC1C=CC(O)=CC=1)CC1C=CC=CC=1 |&1:4,8,17,25,36,47,48,55,66,77,85,97,r|
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Safety

WGK Germany 
3
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D7017
Product name
Dynorphin A Porcine Fragment 1-13
Purity
≥97% (HPLC)
Packaging
1mg
Price
$190
Updated
2024/03/01
Alfa Aesar
Product number
J64015
Product name
Dynorphin A (1-13), porcine
Packaging
1mg
Price
$54.3
Updated
2023/06/20
Alfa Aesar
Product number
J64015
Product name
Dynorphin A (1-13), porcine
Packaging
5mg
Price
$219
Updated
2023/06/20
Apolloscientific
Product number
BISN0009
Product name
PorcineDynorphinA(1-13)
Purity
99%
Packaging
5mg
Price
$225
Updated
2021/12/16
AK Scientific
Product number
9669AJ
Product name
DynorphinA(1-13)
Packaging
5mg
Price
$207
Updated
2021/12/16
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Dynorphin A (1-13) Chemical Properties,Usage,Production

Description

Dynorphin A(1-13), a tridecapeptide of the endogenous opioid peptides, has modest effects in reducing mild opiate withdrawal in humans. Previous studies revealed that dynorphin also potentiates the analgesic effect of morphine in morphine-tolerant rats and mice. The therapeutic potential of dynorphin A(1-13) is limited due to extensive metabolism by human metabolic enzymes resulting in an in vivo half-life of less than one minute. Chemical modifications of dynorphin A(1-13), such as N-methylation of Tyr1 and amidation of the C-terminus have been shown to be effective in protecting against the proteolytic enzymes in human plasma[1].

Application

Dynorphin A (1-13) has been used as a test compound in the field asymmetric waveform ion mobility spectrometry coupled to mass spectrometry (FAIMS/IMS/MS).

Biochem/physiol Actions

Dynorphin A (1-13), a bioactive product of dynorphin A displays interaction with N-methyl- D-aspartate (NMDA) as well as with opioid receptors. It elevates intracellular calcium [Ca2+]i level and contributes to the loss of neurons affecting neuronal viability.

References

[1] B BRUGOS; G H. Metabolism of dynorphin A(1-13).[J]. Pharmazie, 2004.

Dynorphin A (1-13) Preparation Products And Raw materials

Raw materials

Preparation Products

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Dynorphin A (1-13) Suppliers

China 132 France 1 Germany 3 India 1 Japan 2 Switzerland 1 United States 22 USA 1 Global 163
NeoMPS SA
Tel
--
Fax
--
Email
neo@neomps.com
Country
France
ProdList
2083
Advantage
71
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View Lastest Price from Dynorphin A (1-13) manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Dynorphin A (1-13) 72957-38-1
Price
US $0.00/g
Min. Order
1g
Purity
98%min
Supply Ability
1000g
Release date
2023-01-12
Hangzhou Hyper Chemicals Limited
Product
Dynorphin A (1-13) 72957-38-1
Price
US $0.00-0.00/Gram
Min. Order
1Gram
Purity
99%, USP, EP
Supply Ability
100KG
Release date
2024-05-09
Zibo Hangyu Biotechnology Development Co., Ltd
Product
Dynorphin A (1-13) 72957-38-1
Price
US $75.00-750.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-28

72957-38-1, Dynorphin A (1-13)Related Search:

DYNORPHIN B (1-13) H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH LEU-ENKEPHALIN-ARG dynorphin B (1-29) DYNORPHIN B (1-9) TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-TRP-ASP-ASN-GLN-NH2 Dynorphin A (1-13) L-LEUCYL-L-ALANINE (D-ARG6)-DYNORPHIN A (1-13),[D-ARG6]-DYNORPHIN A (1-13), PORCINE DYNORPHIN A (2-13), PORCINE,DYNORPHIN A (2-13) dynorphin amide (1-13), Ala(2)-(5-F-Phe)(4)- [D-ALA2]-DYNORPHIN A (1-13) AMIDE,[DALA2] DYNORPHIN A (1-13), AMIDE, PORCINE [DALA2, DARG6] DYNORPHIN A, (1-13), PORCINE,(D-ALA2,D-ARG6)-DYNORPHIN A (1-13) (ARG11,13)-DYNORPHIN A (1-13)-GLY-NH-(CH2)5-NH2,(ARG11,13)-DYNORPHIN A (1-13)-GLY-5-AMINO-PENTYLAMIDE DYNORPHIN A (1-11) AMIDE DYNORPHIN A (1-10) AMIDE H-LYS-LEU-NH2 LEU-ENKEPHALIN AMIDE

  • TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS
  • TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS 5ACOH 6H2O
  • TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS PORCINE
  • YGGFLRRIRPKLK
  • L-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS
  • DYNORPHIN A PORCINE FRAGMENT 1-13
  • DYNORPHIN A(HUMAN, 1-13)
  • DYNORPHIN A (HUMAN, 1-13) (PORCINE, RAT, BOVINE)
  • DYNORPHIN A (HUMAN, 1-13) (PORCINE, RAT, BOVINE) 5ACOH 6H2O
  • DYNORPHIN A (1-13)
  • DYNORPHIN A (1-13), PORCINE
  • DYNORPHIN 1-13
  • H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-OH
  • DYNORPHIN A (2-13) SYNTHETIC >97% OPIOID AGONIST
  • DYNORPHIN A (1-13) SYNTHETIC >97% OPIOID AGONIST
  • Dynorphin A (1-13) (human, porcine)
  • Porcine dynorphin A(1-13)
  • H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH acetate salt
  • dynorphin A, porcine, fragment 1-13 acetate
  • Dyn(1-13)
  • Dynorphin A(1-13)【pig】
  • Dynorphin A(1-13)【rat】
  • Dynorphin A1-13【pig】
  • Dynorphin (1-17), Dynorphin (1-14)
  • Dynphin A (1-13) Acetate
  • Porcine dynorphin A(1-13),Dynorphin A Porcine Fragment 1-13, BR
  • 1-13-Dynorphin A (swine)
  • Dynorphin A (1-13) USP/EP/BP
  • Dynorphin (1-17), Dynorphin (1-13)(net)
  • 1-13-Dynorphin A acetate salt
  • Dynorphin A (1-13), porcine Acetate
  • sh-Oligopeptide-71
  • 72957-38-1
  • C75H126N24O15
  • Dynorphins
  • Peptides
  • Opioid Peptides
  • BioChemical
  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • Opioid receptor and opioid-like receptor
  • peptide
  • DynorphinsPeptides for Cell Biology
  • Dynorphins
  • Neuropeptides
  • Opioid Peptides