Dynorphin A (1-13)
- Product Name
- Dynorphin A (1-13)
- CAS No.
- 72957-38-1
- Chemical Name
- Dynorphin A (1-13)
- Synonyms
- Dyn(1-13);YGGFLRRIRPKLK;DYNORPHIN 1-13;DYNORPHIN A (1-13);sh-Oligopeptide-71;Dynorphin A1-13【pig】;Dynorphin A(1-13)【pig】;Dynorphin A(1-13)【rat】;DYNORPHIN A(HUMAN, 1-13);Dynphin A (1-13) Acetate
- CBNumber
- CB6699152
- Molecular Formula
- C75H126N24O15
- Formula Weight
- 1603.95
- MOL File
- 72957-38-1.mol
Dynorphin A (1-13) Property
- Density
- 1.39±0.1 g/cm3(Predicted)
- RTECS
- JV7436666
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 3.31±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Water Solubility
- Water: ≥ 60 mg/mL (37.41 mM)
- Sequence
- H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH
- InChI
- InChI=1/C75H126N24O15/c1-7-45(6)61(70(111)94-53(25-17-35-87-75(83)84)71(112)99-36-18-26-58(99)69(110)93-50(21-11-13-31-76)64(105)96-56(38-44(4)5)67(108)95-54(72(113)114)22-12-14-32-77)98-65(106)52(24-16-34-86-74(81)82)91-63(104)51(23-15-33-85-73(79)80)92-66(107)55(37-43(2)3)97-68(109)57(40-46-19-9-8-10-20-46)90-60(102)42-88-59(101)41-89-62(103)49(78)39-47-27-29-48(100)30-28-47/h8-10,19-20,27-30,43-45,49-58,61,100H,7,11-18,21-26,31-42,76-78H2,1-6H3,(H,88,101)(H,89,103)(H,90,102)(H,91,104)(H,92,107)(H,93,110)(H,94,111)(H,95,108)(H,96,105)(H,97,109)(H,98,106)(H,113,114)(H4,79,80,85)(H4,81,82,86)(H4,83,84,87)/t45-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,61-/s3
- InChIKey
- OVVIBUHLQIYUEU-JASZZEBFNA-N
- SMILES
- N1(CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)O)CCCCN)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC1C=CC(O)=CC=1)CC1C=CC=CC=1 |&1:4,8,17,25,36,47,48,55,66,77,85,97,r|
Safety
- WGK Germany
- 3
- HS Code
- 2933998090
N-Bromosuccinimide Price
- Product number
- D7017
- Product name
- Dynorphin A Porcine Fragment 1-13
- Purity
- ≥97% (HPLC)
- Packaging
- 1mg
- Price
- $190
- Updated
- 2024/03/01
- Product number
- J64015
- Product name
- Dynorphin A (1-13), porcine
- Packaging
- 1mg
- Price
- $54.3
- Updated
- 2023/06/20
- Product number
- J64015
- Product name
- Dynorphin A (1-13), porcine
- Packaging
- 5mg
- Price
- $219
- Updated
- 2023/06/20
- Product number
- BISN0009
- Product name
- PorcineDynorphinA(1-13)
- Purity
- 99%
- Packaging
- 5mg
- Price
- $225
- Updated
- 2021/12/16
- Product number
- 9669AJ
- Product name
- DynorphinA(1-13)
- Packaging
- 5mg
- Price
- $207
- Updated
- 2021/12/16
Dynorphin A (1-13) Chemical Properties,Usage,Production
Description
Dynorphin A(1-13), a tridecapeptide of the endogenous opioid peptides, has modest effects in reducing mild opiate withdrawal in humans. Previous studies revealed that dynorphin also potentiates the analgesic effect of morphine in morphine-tolerant rats and mice. The therapeutic potential of dynorphin A(1-13) is limited due to extensive metabolism by human metabolic enzymes resulting in an in vivo half-life of less than one minute. Chemical modifications of dynorphin A(1-13), such as N-methylation of Tyr1 and amidation of the C-terminus have been shown to be effective in protecting against the proteolytic enzymes in human plasma[1].
Application
Dynorphin A (1-13) has been used as a test compound in the field asymmetric waveform ion mobility spectrometry coupled to mass spectrometry (FAIMS/IMS/MS).
Biochem/physiol Actions
Dynorphin A (1-13), a bioactive product of dynorphin A displays interaction with N-methyl- D-aspartate (NMDA) as well as with opioid receptors. It elevates intracellular calcium [Ca2+]i level and contributes to the loss of neurons affecting neuronal viability.
References
[1] B BRUGOS; G H. Metabolism of dynorphin A(1-13).[J]. Pharmazie, 2004.
Dynorphin A (1-13) Preparation Products And Raw materials
Raw materials
Preparation Products
Dynorphin A (1-13) Suppliers
View Lastest Price from Dynorphin A (1-13) manufacturers
- Product
- Dynorphin A (1-13) 72957-38-1
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 1000g
- Release date
- 2023-01-12
- Product
- Dynorphin A (1-13) 72957-38-1
- Price
- US $0.00-0.00/Gram
- Min. Order
- 1Gram
- Purity
- 99%, USP, EP
- Supply Ability
- 100KG
- Release date
- 2024-05-09
- Product
- Dynorphin A (1-13) 72957-38-1
- Price
- US $75.00-750.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-28