Dynorphin A (1-13)

ChemicalBook > CAS DataBase List > Dynorphin A (1-13)

Product Name: Dynorphin A (1-13)
CAS No.: 72957-38-1
Chemical Name: Dynorphin A (1-13)
Synonyms: Dyn(1-13);YGGFLRRIRPKLK;DYNORPHIN 1-13;DYNORPHIN A (1-13);sh-Oligopeptide-71;Dynorphin A1-13【pig】;Dynorphin A(1-13)【pig】;Dynorphin A(1-13)【rat】;DYNORPHIN A(HUMAN, 1-13);Dynphin A (1-13) Acetate
CBNumber: CB6699152
Molecular Formula: C75H126N24O15
Formula Weight: 1603.95
MOL File: 72957-38-1.mol

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Dynorphin A (1-13) Property

Density: 1.39±0.1 g/cm3(Predicted)
RTECS: JV7436666
storage temp.: Inert atmosphere,Store in freezer, under -20°C
pka: 3.31±0.10(Predicted)
form: Solid
Water Solubility: Water: ≥ 60 mg/mL (37.41 mM)
Sequence: H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH
InChI: InChI=1/C75H126N24O15/c1-7-45(6)61(70(111)94-53(25-17-35-87-75(83)84)71(112)99-36-18-26-58(99)69(110)93-50(21-11-13-31-76)64(105)96-56(38-44(4)5)67(108)95-54(72(113)114)22-12-14-32-77)98-65(106)52(24-16-34-86-74(81)82)91-63(104)51(23-15-33-85-73(79)80)92-66(107)55(37-43(2)3)97-68(109)57(40-46-19-9-8-10-20-46)90-60(102)42-88-59(101)41-89-62(103)49(78)39-47-27-29-48(100)30-28-47/h8-10,19-20,27-30,43-45,49-58,61,100H,7,11-18,21-26,31-42,76-78H2,1-6H3,(H,88,101)(H,89,103)(H,90,102)(H,91,104)(H,92,107)(H,93,110)(H,94,111)(H,95,108)(H,96,105)(H,97,109)(H,98,106)(H,113,114)(H4,79,80,85)(H4,81,82,86)(H4,83,84,87)/t45-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,61-/s3
InChIKey: OVVIBUHLQIYUEU-JASZZEBFNA-N
SMILES: N1(CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)O)CCCCN)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC1C=CC(O)=CC=1)CC1C=CC=CC=1 |&1:4,8,17,25,36,47,48,55,66,77,85,97,r|

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Safety

WGK Germany: 3
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D7017
Product name: Dynorphin A Porcine Fragment 1-13
Purity: ≥97% (HPLC)
Packaging: 1mg
Price: $190
Updated: 2024/03/01

Alfa Aesar

Product number: J64015
Product name: Dynorphin A (1-13), porcine
Packaging: 1mg
Price: $54.3
Updated: 2023/06/20

Alfa Aesar

Product number: J64015
Product name: Dynorphin A (1-13), porcine
Packaging: 5mg
Price: $219
Updated: 2023/06/20

Apolloscientific

Product number: BISN0009
Product name: PorcineDynorphinA(1-13)
Purity: 99%
Packaging: 5mg
Price: $225
Updated: 2021/12/16

AK Scientific

Product number: 9669AJ
Product name: DynorphinA(1-13)
Packaging: 5mg
Price: $207
Updated: 2021/12/16

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Dynorphin A (1-13) Chemical Properties,Usage,Production

Description

Dynorphin A(1-13), a tridecapeptide of the endogenous opioid peptides, has modest effects in reducing mild opiate withdrawal in humans. Previous studies revealed that dynorphin also potentiates the analgesic effect of morphine in morphine-tolerant rats and mice. The therapeutic potential of dynorphin A(1-13) is limited due to extensive metabolism by human metabolic enzymes resulting in an in vivo half-life of less than one minute. Chemical modifications of dynorphin A(1-13), such as N-methylation of Tyr1 and amidation of the C-terminus have been shown to be effective in protecting against the proteolytic enzymes in human plasma^[1].

Application

Dynorphin A (1-13) has been used as a test compound in the field asymmetric waveform ion mobility spectrometry coupled to mass spectrometry (FAIMS/IMS/MS).

Biochem/physiol Actions

Dynorphin A (1-13), a bioactive product of dynorphin A displays interaction with N-methyl- D-aspartate (NMDA) as well as with opioid receptors. It elevates intracellular calcium [Ca²⁺]i level and contributes to the loss of neurons affecting neuronal viability.

References

[1] B BRUGOS; G H. Metabolism of dynorphin A(1-13).[J]. Pharmazie, 2004.

Dynorphin A (1-13) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Dynorphin A (1-13) manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Dynorphin A (1-13) 72957-38-1
Price: US $75.00-750.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-28

Hangzhou Hyper Chemicals Limited

Product: Dynorphin A (1-13) 72957-38-1
Price: US $0.00-0.00/Gram
Min. Order: 1Gram
Purity: 99%, USP, EP
Supply Ability: 100KG
Release date: 2024-05-09

Henan Tengmao Chemical Technology Co. LTD

Product: Dynorphin A (1-13) 72957-38-1
Price: US $110.00-90.00/kilogram
Min. Order: 1kilogram
Purity: 99%
Supply Ability: 10 tons/per week
Release date: 2024-03-21

72957-38-1, Dynorphin A (1-13)Related Search:

DYNORPHIN B (1-13) H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH LEU-ENKEPHALIN-ARG dynorphin B (1-29) DYNORPHIN B (1-9) TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-TRP-ASP-ASN-GLN-NH2 Dynorphin A (1-13) L-LEUCYL-L-ALANINE (D-ARG6)-DYNORPHIN A (1-13),[D-ARG6]-DYNORPHIN A (1-13), PORCINE DYNORPHIN A (2-13), PORCINE,DYNORPHIN A (2-13) dynorphin amide (1-13), Ala(2)-(5-F-Phe)(4)- [D-ALA2]-DYNORPHIN A (1-13) AMIDE,[DALA2] DYNORPHIN A (1-13), AMIDE, PORCINE [DALA2, DARG6] DYNORPHIN A, (1-13), PORCINE,(D-ALA2,D-ARG6)-DYNORPHIN A (1-13) (ARG11,13)-DYNORPHIN A (1-13)-GLY-NH-(CH2)5-NH2,(ARG11,13)-DYNORPHIN A (1-13)-GLY-5-AMINO-PENTYLAMIDE DYNORPHIN A (1-11) AMIDE DYNORPHIN A (1-10) AMIDE H-LYS-LEU-NH2 LEU-ENKEPHALIN AMIDE

TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS

TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS 5ACOH 6H2O

TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS PORCINE

YGGFLRRIRPKLK

L-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS

DYNORPHIN A PORCINE FRAGMENT 1-13

DYNORPHIN A(HUMAN, 1-13)

DYNORPHIN A (HUMAN, 1-13) (PORCINE, RAT, BOVINE)

DYNORPHIN A (HUMAN, 1-13) (PORCINE, RAT, BOVINE) 5ACOH 6H2O

DYNORPHIN A (1-13)

DYNORPHIN A (1-13), PORCINE

DYNORPHIN 1-13

H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-OH

DYNORPHIN A (2-13) SYNTHETIC >97% OPIOID AGONIST

DYNORPHIN A (1-13) SYNTHETIC >97% OPIOID AGONIST

Dynorphin A (1-13) (human, porcine)

Porcine dynorphin A(1-13)

H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH acetate salt

dynorphin A, porcine, fragment 1-13 acetate

Dyn(1-13)

Dynorphin A(1-13)【pig】

Dynorphin A(1-13)【rat】

Dynorphin A1-13【pig】

Dynorphin (1-17), Dynorphin (1-14)

Dynphin A (1-13) Acetate

Porcine dynorphin A(1-13),Dynorphin A Porcine Fragment 1-13, BR

1-13-Dynorphin A (swine)

Dynorphin A (1-13) USP/EP/BP

Dynorphin (1-17), Dynorphin (1-13)(net)

1-13-Dynorphin A acetate salt

Dynorphin A (1-13), porcine Acetate

sh-Oligopeptide-71

72957-38-1

C75H126N24O15

Dynorphins

Peptides

Opioid Peptides

BioChemical

Biochemicals and Reagents

Amino Acids and Peptides

Opioid receptor and opioid-like receptor

peptide

DynorphinsPeptides for Cell Biology

Dynorphins

Neuropeptides

Opioid Peptides