Lumateperone
Lumateperone Basic information
- Product Name:
- Lumateperone
- Synonyms:
-
- ITI-722
- Lumateperone
- ITI-722 lumateperone
- 1-(4-fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3‘,4‘:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)butan-1-one
- 313368-91-1Lumateperone(ITI-007)
- 1-Butanone, 1-(4-fluorophenyl)-4-[(6bR,10aS)-2,3,6b,9,10,10a-hexahydro-3-methyl-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-
- 1-(4-fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(9H)-yl)butan-1-one
- 1-(4-Fluorophenyl)-4-[(6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-1-butanone
- CAS:
- 313368-91-1
- MF:
- C24H28FN3O
- MW:
- 393.5
- Product Categories:
-
- API
- Mol File:
- 313368-91-1.mol
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Lumateperone Chemical Properties
- Boiling point:
- 556.4±50.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- pka
- 9.10±0.20(Predicted)
- form
- Oil
- color
- Colorless to light yellow
- InChIKey
- HOIIHACBCFLJET-SFTDATJTSA-N
- SMILES
- C(C1=CC=C(F)C=C1)(=O)CCCN1C[C@@]2([H])C3=CC=CC4=C3N([C@@]2([H])CC1)CCN4C
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Lumateperone Usage And Synthesis
Physical Form
white solid
Description
Lumateperone is a novel antipsychotic agent with a unique mechanism of
action with high 5-hydroxytryptamine 2A(5-HT2A) blocking activity. A
Phase 2 study in treatment of insomnia revealed strong evidence of
efficacy, with no impairment of next-day cognition.
Uses
Lumateperone was a drug developed for the treatment of schizophrenia. May have applications in bipolar depression.
Synthesis
Synthesis of Lumateperone
in vivo
Lumateperone (i.p., 1-10 mg/kg) promotes NMDA and AMPA-induced currents in a dopamine D1 receptor-dependent manner and increases the release of dopamine and glutamate in rat mPFC slices[2].
| Animal Model: | Adult male Sprague-Dawley rats[2] |
| Dosage: | 1-10 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Inhibited avoidance response at concentrations of 1, 3 and 10 mg/kg after 20 minutes. Promoted NMDA and AMPA-sensitive currents, also significantly increased dopamine and glutamate release at 10 mg/kg in mPFC cone cells of rat. |
IC 50
D1 Receptor; D2 Receptor
storage
Store at 0-8℃
References
[1] Patent: US2004/220178, 2004, A1
LumateperoneSupplier
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