ChemicalBook > Product Catalog > Organic Chemistry > Carboxylic acids and derivatives > (2S)-2-amino-6-{[(prop-2-yn-1-yloxy)carbonyl]amino}hexanoic acid
(2S)-2-amino-6-{[(prop-2-yn-1-yloxy)carbonyl]amino}hexanoic acid
(2S)-2-amino-6-{[(prop-2-yn-1-yloxy)carbonyl]amino}hexanoic acid Basic information
- Product Name:
- (2S)-2-amino-6-{[(prop-2-yn-1-yloxy)carbonyl]amino}hexanoic acid
- Synonyms:
-
- (2S)-2-amino-6-{[(prop-2-yn-1-yloxy)carbonyl]amino}hexanoic acid
- Click-Amino-Acid / PrK - HCl-salt
- N6-((prop-2-yn-1-yloxy)carbonyl)-L-lysine
- N-propargyloxycarbonyl-L-lysine
- L-Lysine, N6-[(2-propyn-1-yloxy)carbonyl]-
- N6-[(2-propynyloxy)carbonyl]-L-lysine HCl
- N-Propargyl-lysine
- CAS:
- 1215204-46-8
- MF:
- C10H16N2O4
- MW:
- 228.24
- Product Categories:
-
- SiChem
- Mol File:
- 1215204-46-8.mol
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(2S)-2-amino-6-{[(prop-2-yn-1-yloxy)carbonyl]amino}hexanoic acid Chemical Properties
- storage temp.
- Store at -20°C
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(2S)-2-amino-6-{[(prop-2-yn-1-yloxy)carbonyl]amino}hexanoic acid Usage And Synthesis
Biological Activity
N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals[1][2]. Labeling of N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH)-carrying cellular proteins, such as Sec61β, Htt74Q and the histone H3 variant H3.3, with a sensitive Raman tag by click chemistry for molecular hyperspectral SRS imaging[1].
References
[1]. Kyung Jin Lee, et al. Site-Specific Labeling of Proteins Using Unnatural Amino Acids. Mol Cells. 2019 May 31;42(5):386-396. [2]. Enke HEIKE, et al. Modified microcystins and nodularins.WO2018206715A2
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