N-cyclopropene-L-Lysine Chemical Properties

Boiling point:

452.1±40.0 °C(Predicted)

Density 

1.208±0.06 g/cm3(Predicted)

form 

Solid

pka

2.53±0.24(Predicted)

color 

White to off-white

N-cyclopropene-L-Lysine Usage And Synthesis

Uses

CypK (N-Cyclopropene-L-Lysine), a cyclopropene derivative of lysine, is efficiently incorporated into antibodies through genetic-code expansion. CypK is a minimal bioorthogonal handle for the creation of stable therapeutic protein conjugates[1][2].

References

[1] Oller-Salvia B. Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction. J Vis Exp. 2018 Sep 14;(139):58066. DOI:10.3791/58066
[2] Oller-Salvia B, et, al. Rapid and Efficient Generation of Stable Antibody-Drug Conjugates via an Encoded Cyclopropene and an Inverse-Electron-Demand Diels-Alder Reaction. Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2831-2834. DOI:10.1002/anie.201712370

N-cyclopropene-L-Lysine(1610703-09-7)Related Product Information

• N-Pentyn1yloxycarbonyl]-L-lysine
• (2S)-2-amino-6-{[(prop-2-yn-1-yloxy)carbonyl]amino}hexanoic acid
• N-(4E)-TCO-L-lysine
• N-(2E)-TCO-L-lysine
• N-Cyclopropene-D-Mannopyranose-tetraacetated