Derazantinib
Derazantinib Basic information
- Product Name:
- Derazantinib
- Synonyms:
-
- (6R)-6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-Benzo[h]quinazolin-2-amine
- ARQ-087
- CPD1093
- Derazantinib
- Derazantinib (ARQ-087)
- (R)-6-(2-fluorophenyl)-N-(3-(2-((2-methoxyethyl)amino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine
- ARQ-087;ARQ087;ARQ 087;CPD1093
- CS-2677
- CAS:
- 1234356-69-4
- MF:
- C29H29FN4O
- MW:
- 468.57
- Mol File:
- 1234356-69-4.mol
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Derazantinib Chemical Properties
- Boiling point:
- 615.1±65.0 °C(Predicted)
- Density
- 1.218±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:47.67(Max Conc. mg/mL);101.73(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);64.02(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.53(Max Conc. mM) - form
- A crystalline solid
- pka
- 9.04±0.19(Predicted)
- color
- White to yellow
- InChIKey
- KPJDVVCDVBFRMU-AREMUKBSSA-N
- SMILES
- N1=C2C(C[C@@H](C3=CC=CC=C3F)C3=CC=CC=C32)=CN=C1NC1=CC=CC(CCNCCOC)=C1
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Derazantinib Usage And Synthesis
Uses
Derazantinib is an intermediate in the preparation of imidazopyridinyl compounds for treating proliferative disorders like cancer, Proteus syndrome and others.
in vivo
Derazantinib is effective at inhibiting tumor growth in FGFR2 altered, SNU-16 and NCI-H716, xenograft tumor models with gene amplifications and fusions[1]. Most of the embryos exhibit abnormal external phenotype (81.3%) in Derazantinib-injected wings, possibly due to inhibition of proliferation of limb bud mesenchyme. The wings are shorter and thinner, with skeletal phenotype typical for FGFR inhibition, where ulna and radius are shorter or smaller in size, or occasionally missing completely[2].
IC 50
FGFR1: 4.5 nM (IC50); FGFR2: 1.8 nM (IC50); FGFR3: 4.5 nM (IC50)
DerazantinibSupplier
ShangHai Caerulum Pharma Discovery Co., Ltd. Gold
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Shanghai Weishukur Medical Technology Co., LTD Gold
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Dalian Meilun Biotech Co., Ltd.
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MedChemexpress LLC
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Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696，15000506266 15000506266