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Derazantinib

Product Name
Derazantinib
CAS No.
1234356-69-4
Chemical Name
Derazantinib
Synonyms
CS-2677;CPD1093;ARQ-087;Derazantinib;Derazantinib (ARQ-087);Derazantinib, 10 mM in DMSO;ARQ-087;ARQ087;ARQ 087;CPD1093;ARQ-087;ARQ087;DERAZANTINIB;ARQ 087;ARQ 087,Derazantinib,Fibroblast growth factor receptor,inhibit,FGFR,ARQ087,Inhibitor;(R)-6-(2-fluorophenyl)-N-(3-(2-((2-methoxyethyl)amino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine
CBNumber
CB63133460
Molecular Formula
C29H29FN4O
Formula Weight
468.57
MOL File
1234356-69-4.mol
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Derazantinib Property

Boiling point:
615.1±65.0 °C(Predicted)
Density 
1.218±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:47.67(Max Conc. mg/mL);101.73(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);64.02(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.53(Max Conc. mM)
form 
A crystalline solid
pka
9.04±0.19(Predicted)
color 
White to yellow
InChIKey
KPJDVVCDVBFRMU-AREMUKBSSA-N
SMILES
N1=C2C(C[C@@H](C3=CC=CC=C3F)C3=CC=CC=C32)=CN=C1NC1=CC=CC(CCNCCOC)=C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27636
Product name
Derazantinib
Packaging
1mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
27636
Product name
Derazantinib
Packaging
25mg
Price
$1139
Updated
2024/03/01
Cayman Chemical
Product number
27636
Product name
Derazantinib
Packaging
5mg
Price
$388
Updated
2024/03/01
Cayman Chemical
Product number
27636
Product name
Derazantinib
Packaging
10mg
Price
$593
Updated
2024/03/01
Usbiological
Product number
446125
Product name
Derazantinib
Packaging
1mg
Price
$616
Updated
2021/12/16
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Derazantinib Chemical Properties,Usage,Production

Uses

Derazantinib is an intermediate in the preparation of imidazopyridinyl compounds for treating proliferative disorders like cancer, Proteus syndrome and others.

in vivo

Derazantinib is effective at inhibiting tumor growth in FGFR2 altered, SNU-16 and NCI-H716, xenograft tumor models with gene amplifications and fusions[1]. Most of the embryos exhibit abnormal external phenotype (81.3%) in Derazantinib-injected wings, possibly due to inhibition of proliferation of limb bud mesenchyme. The wings are shorter and thinner, with skeletal phenotype typical for FGFR inhibition, where ulna and radius are shorter or smaller in size, or occasionally missing completely[2].

IC 50

FGFR1: 4.5 nM (IC50); FGFR2: 1.8 nM (IC50); FGFR3: 4.5 nM (IC50)

Derazantinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Derazantinib Suppliers

China 81 India 1 United States 6 USA 1 Global 89
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Shanghai Weishukur Medical Technology Co., LTD
Tel
15250615384
Email
316228842@qq.com
Country
China
ProdList
319
Advantage
58
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4769
Advantage
55
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
984
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2991
Advantage
58

1234356-69-4, DerazantinibRelated Search:

Alectinib Lenvatinib E-3810 Tirabrutinib JNJ-7706621

  • (6R)-6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-Benzo[h]quinazolin-2-amine
  • ARQ-087
  • CPD1093
  • Derazantinib
  • Derazantinib (ARQ-087)
  • (R)-6-(2-fluorophenyl)-N-(3-(2-((2-methoxyethyl)amino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine
  • ARQ-087;ARQ087;ARQ 087;CPD1093
  • CS-2677
  • ARQ-087;ARQ087;DERAZANTINIB;ARQ 087
  • Benzo[h]quinazolin-2-amine, 6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-, (6R)-
  • ARQ 087,Derazantinib,Fibroblast growth factor receptor,inhibit,FGFR,ARQ087,Inhibitor
  • Derazantinib, 10 mM in DMSO
  • 1234356-69-4
  • C29H29FN4O