ChemicalBook > CAS DataBase List > Derazantinib

Derazantinib

Product Name: Derazantinib
CAS No.: 1234356-69-4
Chemical Name: Derazantinib
Synonyms: CS-2677;CPD1093;ARQ-087;Derazantinib;Derazantinib (ARQ-087);Derazantinib, 10 mM in DMSO;ARQ-087;ARQ087;ARQ 087;CPD1093;ARQ-087;ARQ087;DERAZANTINIB;ARQ 087;ARQ 087,Derazantinib,Fibroblast growth factor receptor,inhibit,FGFR,ARQ087,Inhibitor;(R)-6-(2-fluorophenyl)-N-(3-(2-((2-methoxyethyl)amino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine
CBNumber: CB63133460
Molecular Formula: C29H29FN4O
Formula Weight: 468.57
MOL File: 1234356-69-4.mol

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Derazantinib Property

Boiling point:: 615.1±65.0 °C(Predicted)
Density: 1.218±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:47.67(Max Conc. mg/mL);101.73(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);64.02(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.53(Max Conc. mM)
form: A crystalline solid
pka: 9.04±0.19(Predicted)
color: White to yellow
InChIKey: KPJDVVCDVBFRMU-AREMUKBSSA-N
SMILES: N1=C2C(C[C@@H](C3=CC=CC=C3F)C3=CC=CC=C32)=CN=C1NC1=CC=CC(CCNCCOC)=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27636
Product name: Derazantinib
Packaging: 1mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 27636
Product name: Derazantinib
Packaging: 25mg
Price: $1139
Updated: 2024/03/01

Cayman Chemical

Product number: 27636
Product name: Derazantinib
Packaging: 5mg
Price: $388
Updated: 2024/03/01

Cayman Chemical

Product number: 27636
Product name: Derazantinib
Packaging: 10mg
Price: $593
Updated: 2024/03/01

Usbiological

Product number: 446125
Product name: Derazantinib
Packaging: 1mg
Price: $616
Updated: 2021/12/16

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Derazantinib Chemical Properties,Usage,Production

Uses

Derazantinib is an intermediate in the preparation of imidazopyridinyl compounds for treating proliferative disorders like cancer, Proteus syndrome and others.

in vivo

Derazantinib is effective at inhibiting tumor growth in FGFR2 altered, SNU-16 and NCI-H716, xenograft tumor models with gene amplifications and fusions^[1]. Most of the embryos exhibit abnormal external phenotype (81.3%) in Derazantinib-injected wings, possibly due to inhibition of proliferation of limb bud mesenchyme. The wings are shorter and thinner, with skeletal phenotype typical for FGFR inhibition, where ulna and radius are shorter or smaller in size, or occasionally missing completely^[2].

IC 50

FGFR1: 4.5 nM (IC₅₀); FGFR2: 1.8 nM (IC₅₀); FGFR3: 4.5 nM (IC₅₀)

Derazantinib Preparation Products And Raw materials

Raw materials

Preparation Products

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1234356-69-4, DerazantinibRelated Search:

Alectinib Lenvatinib E-3810 Tirabrutinib JNJ-7706621

(6R)-6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-Benzo[h]quinazolin-2-amine

ARQ-087

CPD1093

Derazantinib

Derazantinib (ARQ-087)

(R)-6-(2-fluorophenyl)-N-(3-(2-((2-methoxyethyl)amino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine

ARQ-087;ARQ087;ARQ 087;CPD1093

CS-2677

ARQ-087;ARQ087;DERAZANTINIB;ARQ 087

Benzo[h]quinazolin-2-amine, 6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-, (6R)-

ARQ 087,Derazantinib,Fibroblast growth factor receptor,inhibit,FGFR,ARQ087,Inhibitor

Derazantinib, 10 mM in DMSO

1234356-69-4

C29H29FN4O