NFκB Inhibitor
NFκB Inhibitor Basic information
- Product Name:
- NFκB Inhibitor
- Synonyms:
-
- FGF-4 PRECURSOR (7-22) (HUMAN)-EBP-1 (359-368) (HUMAN)
- FIBROBLAST GROWTH FACTOR-4 PRECURSOR (7-22) (HUMAN)-NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT (359-368) (HUMAN)
- H-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-VAL-GLN-ARG-LYS-ARG-GLN-LYS-LEU-MET-PRO-OH
- HST-1 PRECURSOR (7-22) (HUMAN)-DNA-BINDING FACTOR KBF1 (359-368) (HUMAN)
- AAVALLPAVLLALLAPVQRKRQKLMP
- NF-KAPPA-B SN50
- NF-KAPPA-B SN50, CELL-PERMEABLE INHIBITOR PEPTIDE
- NF-KAPPAB SN50, CELL-PERMEABLE INHIBITORY PEPTIDE
- CAS:
- 213546-53-3
- MF:
- C129H230N36O29S
- MW:
- 2781.5
- Mol File:
- 213546-53-3.mol
NFκB Inhibitor Chemical Properties
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- form
- film
- color
- colorless
- Water Solubility
- Water : ≥ 50 mg/mL (17.98 mM)
- Sequence
- Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro
NFκB Inhibitor Usage And Synthesis
Uses
NFkappaB Inhibitor is inhibits translocation of the NFκB active complex into the nucleus.
Biochem/physiol Actions
SN50 is an NF-κB cell permeable inhibitory peptide. The SN50 sequence contains the nuclear localization sequence (NLS residues 360-369) of the transcription factor NFκB p50 linked to a peptide cell-permeabilization sequence, the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). SN50 Peptide inhibits translocation of the NF-κB active complex into the nucleus.
in vivo
Treatment with SN50 accelerates the recovery of motor functional outcome from 1st to 4th day. Animals subjected to SN50 pretreatment demonstrate a significant decrease in the visuospatial learning latencies relative to the control group at 7 and 8 days post-TBI. Pretreatment with SN50 results in a significant reduction of NF-κB p65 protein levels from 6 to 48 h post-TBI and TNF-a protein levels from 12 to 48 h post-TBI[1].
IC 50
NF-κB
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