Dehydrocorydaline chloride
Dehydrocorydaline chloride Basic information
- Product Name:
- Dehydrocorydaline chloride
- Synonyms:
-
- Dehydrocorydaline chloride
- Dehydrocorydaline chloride, 99.95%
- 13-Methylpalmatine chloride
- inhibit,Bcl-2 Family,Dehydrocorydaline chloride,Autophagy,PARP,poly ADP ribose polymerase,Caspase,13-Methylpalmatine,Dehydrocorydaline,p38 MAPK,Parasite,Inhibitor
- CAS:
- 10605-03-5
- MF:
- C22H24ClNO4
- MW:
- 401.88326
- Mol File:
- 10605-03-5.mol
Dehydrocorydaline chloride Chemical Properties
- Melting point:
- 191-193 °C (decomp)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 20 mg/ml
- form
- A solid
Dehydrocorydaline chloride Usage And Synthesis
Biological Activity
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid isolated from the traditional Chinese medicine Corydalis yanhusuo. It regulates Bax, Bcl-2 protein expression; activates caspase-7, caspase-8, and inactivates PARP. Also Dehydrocorydaline chloride can enhance the activation of p38 MAPK and has anti-inflammatory and anti-cancer effects. .
in vitro
Dehydrocorydaline significantly inhibits MCF-7 cell proliferation in a dose-dependent manner, which can be reversed by a caspase-8 inhibitor, Z-IETD-FMK. Dehydrocorydaline increases DNA fragments without affecting ΔΨm. Western blotting assay shows that dehydrocorydaline dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression.
in vivo
Dehydrocorydaline (3.6, 6 or 10 mg/kg, ip) shows a dose-dependent anticiceptive effect in the acetic acid-induced writhing test and significantly attenuates the formalin-induced pain responses in mice. In the formalin test , dehydrocorydaline decreases the expression of caspase 6 (CASP6), TNF-α, IL-1β and IL-6 proteins in the spinal cord. These findings confirm that Dehydrocorydaline has antinociceptive effects in mice.
target
p38 MAPK
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