Basic information Safety Supplier Related

Dehydrocorydaline chloride

Basic information Safety Supplier Related

Dehydrocorydaline chloride Basic information

Product Name:
Dehydrocorydaline chloride
Synonyms:
  • Dehydrocorydaline chloride
  • Dehydrocorydaline chloride, 99.95%
  • 13-Methylpalmatine chloride
  • inhibit,Bcl-2 Family,Dehydrocorydaline chloride,Autophagy,PARP,poly ADP ribose polymerase,Caspase,13-Methylpalmatine,Dehydrocorydaline,p38 MAPK,Parasite,Inhibitor
  • 2,3,9,10-Tetramethoxy-13-methyl-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium chloride
CAS:
10605-03-5
MF:
C22H24ClNO4
MW:
401.88326
Mol File:
10605-03-5.mol
More
Less

Dehydrocorydaline chloride Chemical Properties

Melting point:
191-193 °C (decomp)
storage temp. 
Store at -20°C
solubility 
DMSO: 20 mg/ml
form 
A solid
color 
Light yellow to yellow
More
Less

Safety Information

HS Code 
2933399990
Toxicity
mouse,LD50,intravenous,9500ug/kg (9.5mg/kg),United States Patent Document. Vol. #3849561,
More
Less

Dehydrocorydaline chloride Usage And Synthesis

Biological Activity

Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid isolated from the traditional Chinese medicine Corydalis yanhusuo. It regulates Bax, Bcl-2 protein expression; activates caspase-7, caspase-8, and inactivates PARP. Also Dehydrocorydaline chloride can enhance the activation of p38 MAPK and has anti-inflammatory and anti-cancer effects. .

in vitro

Dehydrocorydaline significantly inhibits MCF-7 cell proliferation in a dose-dependent manner, which can be reversed by a caspase-8 inhibitor, Z-IETD-FMK. Dehydrocorydaline increases DNA fragments without affecting ΔΨm. Western blotting assay shows that dehydrocorydaline dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression.

in vivo

Dehydrocorydaline (3.6, 6 or 10 mg/kg, ip) shows a dose-dependent anticiceptive effect in the acetic acid-induced writhing test and significantly attenuates the formalin-induced pain responses in mice. In the formalin test , dehydrocorydaline decreases the expression of caspase 6 (CASP6), TNF-α, IL-1β and IL-6 proteins in the spinal cord. These findings confirm that Dehydrocorydaline has antinociceptive effects in mice.

target

p38 MAPK

Dehydrocorydaline chlorideSupplier

MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Email
3008007409@qq.com
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Email
psaitong@jm-bio.com
Musechem
Tel
+1-800-259-7612
Email
info@musechem.com
More
Less

Dehydrocorydaline chloride(10605-03-5)Related Product Information