Azido-PEG3-S-PEG4-t-butyl ester Usage And Synthesis

Description

Azido-PEG3-S-PEG4-t-butyl ester is a PEG linker containing one azide group and one t-butyl protected carboxyl group. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group (COOH) prevents self coupling or polymerization under standard acid/amine or acid/hydroxyl coupling conditions.

Uses

Azido-PEG3-S-PEG4-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-S-PEG4-t-butyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Azido-PEG3-S-PEG4-t-butyl ester(2055041-19-3)Related Product Information

• Azido-PEG3-Val-Cit-PAB-PNP
• Azido-PEG3-S-PEG4-propargyl
• Azdo-PEG3-S-PEG3-Azide
• Azido-PEG4-NHBoc
• Azido-PEG3-Val-Cit-PAB-OH