Mal-PEG8-t-butyl ester Chemical Properties

Boiling point:

625.7±55.0 °C(Predicted)

Density 

1.144±0.06 g/cm3(Predicted)

storage temp. 

-20°C, stored under nitrogen

solubility 

Soluble in Water, DMSO, DMF, DCM

pka

-2.34±0.20(Predicted)

form 

Oil

color 

Colorless to light yellow

Mal-PEG8-t-butyl ester Usage And Synthesis

Description

Mal-PEG8-t-butyl ester is a PEG linker containing a maleimide group and a t-butyl ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Uses

Mal-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Mal-PEG8-t-butyl ester(2055048-43-4)Related Product Information

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• Maleimido-mono-amide-NOTA
• Mal-PEG8-acid
• Mal-PEG20K-OMe
• Maleimide-SS-DBCO
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• 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethyl]amino]-2-oxoethyl]-, 1,4,7-tris(1,1-dimethylethyl) ester
• Mal-PEG8-NHS ester
• Mal-SS-NHS
• Mal-PEG8-Mal
• Mal-PEG10K-OMe