N-BOC-IMIDAZOLE
N-BOC-IMIDAZOLE Basic information
- Product Name:
- N-BOC-IMIDAZOLE
- Synonyms:
-
- 1H-Imidazole-1-carboxylic acid, 1,1-dimethylethyl ester
- tert-Butyl 1H-imidazole-1-carboxylate
- BOC-IMIDAZOLE
- N-Boc-imidazole,98%
- 1-(TERT-BUTOXYCARBONYL)IMIDAZOLE
- N-BOC-IMIDAZOLE
- N-T-BOC-IMIDAZOLE
- N-TERT-BUTOXYCARBONYLIMIDAZOLE
- CAS:
- 49761-82-2
- MF:
- C8H12N2O2
- MW:
- 168.19
- EINECS:
- 256-475-1
- Product Categories:
-
- Building Blocks
- Chemical Synthesis
- Heterocyclic Building Blocks
- Protective Reagents (Peptide Synthesis)
- Biochemistry
- Peptide Synthesis
- Synthetic Organic Chemistry
- Building Blocks
- Heterocyclic Building Blocks
- Imidazoles
- Protection & Derivatization Reagents (for Synthesis)
- Mol File:
- 49761-82-2.mol
N-BOC-IMIDAZOLE Chemical Properties
- Melting point:
- 45-47 °C(lit.)
- Boiling point:
- 147-150 °C(lit.)
- Density
- 1.1835 (rough estimate)
- refractive index
- 1.4200 (estimate)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- Soluble in hexane, acetone, and DMF.
- form
- powder to crystal
- pka
- 3.49±0.10(Predicted)
- color
- White to Almost white
- Sensitive
- Moisture Sensitive
- BRN
- 607792
- InChI
- InChI=1S/C8H12N2O2/c1-8(2,3)12-7(11)10-5-4-9-6-10/h4-6H,1-3H3
- InChIKey
- MTBKGWHHOBJMHJ-UHFFFAOYSA-N
- SMILES
- C1N(C(OC(C)(C)C)=O)C=CN=1
- CAS DataBase Reference
- 49761-82-2(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
N-BOC-IMIDAZOLE Usage And Synthesis
Chemical Properties
White powder
Uses
1-Boc-imidazole is used in the preparation of water soluble polyrotaxane, via modification of α-cyclodextrin in the presence of KOH and N,N?-carbonyldiimidazole.
Synthesis Reference(s)
1. (a) Barcelo, G.; Senet, J. P.; Sennyey, G. JOC 1985, 50, 3951. (b) Klee, W.; Brenner, M. HCA 1961, 2151.
General Description
1-(tert-butoxycarbonyl)imidazole is an imidazole derivative. Its gas-phase elimination kinetics study has been studied both theoretically and experimentally.
Synthesis
1-(t-butoxycarbonyl)imidazole can be synthesized by the reaction of imidazole and 1,2,2,2-tetrachloroethyl-t-butyl carbonate or the reaction of t-butanol and N,N′-carbonyldiimidazole in high yield.1
References
[1] Tetrahedron Letters, 2008, vol. 49, # 16, p. 2527 - 2532
[2] Tetrahedron Letters, 2011, vol. 52, # 12, p. 1260 - 1264
[3] Monatshefte fur Chemie, 2011, vol. 142, # 10, p. 1035 - 1043
[4] RSC Advances, 2014, vol. 4, # 47, p. 24544 - 24550
[5] Tetrahedron Letters, 2017, vol. 58, # 7, p. 629 - 633
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N-BOC-IMIDAZOLE(49761-82-2)Related Product Information
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- SPECS AI-942/42301869