[1,1'-Biphenyl]-3-carboxamide, 6-(1-aminoethyl)-4'-fluoro-N-4-pyridinyl- Chemical Properties

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

Solid

color 

White to light yellow

[1,1'-Biphenyl]-3-carboxamide, 6-(1-aminoethyl)-4'-fluoro-N-4-pyridinyl- Usage And Synthesis

Uses

ROCK-IN-1 is a potent inhibitor of ROCK, with an IC50 of 1.2 nM for ROCK2.

IC 50

ROCK2: 1.2 nM (IC₅₀)

References

[1] Boland S, et al. 3-[2-(Aminomethyl)-5-[(pyridin-4-yl)carbamoyl]phenyl] benzoates as soft ROCK inhibitors. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6442-6. DOI:10.1016/j.bmcl.2013.09.040