Argatroban Impurity 23 Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMF: soluble,DMSO: soluble,Methanol: soluble

form 

A solid

Argatroban Impurity 23 Usage And Synthesis

Description

Argatroban-d₃ is intended for use as an internal standard for the quantification of argatroban by GC- or LC-MS. Argatroban is a reversible inhibitor of thrombin (IC₅₀s = 0.01 and 0.09 μM for the free and clot-bound forms, respectively). It is selective for thrombin over factor Xa, trypsin, plasmin, and tissue plasminogen activator (K_is = 0.0045, 53, 0.19, 25.7, and 87.7 μM, respectively). It inhibits thrombin-induced platelet aggregation in washed isolated guinea pig platelets with an IC₅₀ value of 0.077 μM. Argatroban (3.2 mg/kg, s.c.) decreases thrombus formation in a guinea pig model of iron chloride-induced arterial thrombosis. Formulations containing argatroban have been used in the prevention or treatment of thrombosis in patients with heparin-induced thrombocytopenia.

Uses

Labelled synthetic thrombin inhibitor. Antithrombotic.

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