[glycyl-κN-L-histidyl-κN,κN3-L-lysinato(2-)]-Copper, monoacetate (9CI)
[glycyl-κN-L-histidyl-κN,κN3-L-lysinato(2-)]-Copper, monoacetate (9CI) Basic information
- Product Name:
- [glycyl-κN-L-histidyl-κN,κN3-L-lysinato(2-)]-Copper, monoacetate (9CI)
- Synonyms:
-
- [glycyl-κN-L-histidyl-κN,κN3-L-lysinato(2-)]-Copper, monoacetate (9CI)
- (2S)-6-amino-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoate
- GHK-Cu (acetate)
- Glycyl-L-Histidyl-L-Lysine Copper acetate(1:1)
- GHK-Cuacetat
- N2-(N-glycyl-L-histidyl)-L-Lysine,coppercomplex,acetate
- GHK-CU (1:1) acetate salt
- CAS:
- 300801-03-0
- MF:
- C16H25CuN6O6
- MW:
- 460.96
- Mol File:
- 300801-03-0.mol
[glycyl-κN-L-histidyl-κN,κN3-L-lysinato(2-)]-Copper, monoacetate (9CI) Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- PBS (pH 7.2): 5 mg/ml
- form
- A solid
[glycyl-κN-L-histidyl-κN,κN3-L-lysinato(2-)]-Copper, monoacetate (9CI) Usage And Synthesis
Description
GHK-Cu acetate is a complex of the tripeptide Gly-His-Lys and a copper(II) ion that has wound healing and anti-inflammatory activities. It increases proliferation and the levels of collagen and secreted pro-matrix metalloproteinase-2 (MMP-2) in isolated human fibroblasts. GHK-Cu increases levels of collagen and glycosaminoglycans (GAGs) and the expression of decorin in the wound tissue of rats. It decreases LPS-induced increases in the levels of reactive oxygen species (ROS), IL-6, and TNF-α in RAW 264.7 cells when used at a concentration of 10 μM.3 GHK-Cu (10 μg/g) prevents LPS-induced decreases in lung superoxide dismutase (SOD) activity and glutathione (GSH) levels and reduces LPS-induced increases in the number of cells and the level of total protein in bronchoalveolar lavage fluid (BALF) in a mouse model of acute lung injury.
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