QC6352
QC6352 Basic information
- Product Name:
- QC6352
- Synonyms:
-
- CPD1548
- QC6352
- 4-Pyridinecarboxylic acid, 3-[[[(1R)-1,2,3,4-tetrahydro-6-(methylphenylamino)-1-naphthalenyl]methyl]amino]-
- QC-6352,QC6352
- CAS:
- 1851373-36-8
- MF:
- C24H25N3O2
- MW:
- 387.47
- Mol File:
- 1851373-36-8.mol
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QC6352 Chemical Properties
- Boiling point:
- 681.6±55.0 °C(Predicted)
- Density
- 1.243±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 25 mg/mL (64.52 mM)
- pka
- 1.55±0.36(Predicted)
- form
- Solid
- color
- Light yellow to yellow
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QC6352 Usage And Synthesis
Uses
3-[[[(1R)-1,2,3,4-Tetrahydro-6-(methylphenylamino)-1-naphthalenyl]methyl]amino]-4-Pyridinecarboxylic Acid is also known as a KDM4 inhibitor exhibiting antiproliferative effects in cancer models.
in vivo
QC6352 strongly affects tumor growth and final tumor weight of both BCSC1 and BCSC2 xenografts. Treatment with QC6352 is well tolerated and does not affect body weight of the mice. Results demonstrate that treatment with the KDM4 inhibitor QC6352 blocks BCSC xenograft tumor growth[2].
IC 50
KDM4; KDM5B: 750 nM (IC50); KDM4A: 104 nM (IC50); KDM4B: 56 nM (IC50); KDM4C: 35 nM (IC50); KDM4D: 104 nM (IC50)
QC6352Supplier
Nanjing Chemlin Chemical Co., Ltd
- Tel
- 025-83697070
- info@chemlin.com.cn
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
Sichuan Wei Keqi Biological Technology Co., Ltd.
- Tel
- 028-81700200 18116577057
- 3003855609@qq.com
Jinan Yaoyan Pharmaceutical Co., Ltd.
- Tel
- jnyaoyan@163.com
Angel Pharmatech, Ltd.
- Tel
- 17317130613
- 3358272972@qq.com