TC-I 2014
TC-I 2014 Basic information
- Product Name:
- TC-I 2014
- Synonyms:
-
- 3-[7-(TRIFLUOROMETHYL)-5-[2-(TRIFLUOROMETHYL)PHENYL]-1H-BENZIMIDAZOL-2-YL]-1-OXA-2-AZASPIRO[4.5]DEC-2-ENE
- TC-I 2014
- VSMFCZZEKTVDHM-UHFFFAOYSA-N
- 1-Oxa-2-azaspiro[4.5]dec-2-ene, 3-[7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl]-
- TCI 2014,TC I 2014
- 3-(7-(Trifluoromethyl)-5-(2-(trifluoromethyl)phenyl)-1H-benzo[d]imidazol-2-yl)-1-oxa-2-azaspiro[4.5]dec-2-ene
- 3-[7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-1,3-benzodiazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene
- CAS:
- 1221349-53-6
- MF:
- C23H19F6N3O
- MW:
- 467.41
- Mol File:
- 1221349-53-6.mol
More
Less
TC-I 2014 Chemical Properties
- Boiling point:
- 564.3±60.0 °C(Predicted)
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 7.01±0.30(Predicted)
- color
- White to off-white
More
Less
TC-I 2014 Usage And Synthesis
Uses
TC-I 2014 is a potent TRPM8 antagonist exhibiting antiallodynic properties in pain models.
in vivo
TC-I 2014 (10 mg/kg, Orally once) completely prevents icilin-induced WDS[1].
| Animal Model: | TC-I 2014 (10 mg/kg, Orally once) completely prevents icilin-induced WDS[1]. |
| Dosage: | 3, 5.6, 10 mg/kg. |
| Administration: | Orally once. |
| Result: | Produced greater than 90% inhibition at 3, 5.6, and 10 mg/kg administered 2 h prior to icilin challenge. |
storage
Store at +4°C
TC-I 2014Supplier
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghai Beckham Medical Technology Co., Ltd
- Tel
- 13816613772
- huahero21@sina.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
Jinan Yaoyan Pharmaceutical Co., Ltd.
- Tel
- jnyaoyan@163.com
Fan De(Beijing) Biotechnology Co., Ltd.
- Tel
- 15911056312
- liming@bio-fount.com