Mc-Val-Ala-PAB
Mc-Val-Ala-PAB Basic information
- Product Name:
- Mc-Val-Ala-PAB
- Synonyms:
-
- Mc-Val-Ala-PAB
- L-Alaninamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N-[4-(hydroxymethyl)phenyl]-
- Mc-Val-Ala-PAB-OH
- 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide
- Mc ?Val ?Ala ?PAB,Inhibitor,ADC Linkers,Mc?Val?Ala?PAB,Antibody-drug conjugates linkers,inhibit
- 6-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)-N-[(S)-1-[[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-2-propyl]amino]-3-methyl-1-oxo-2-butyl]hexanamide
- 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-[(1S)-1-{[(1S)-1-[(4-(hydroxymethyl)phenyl)carbamoyl]ethyl]carbamoyl}-2-methylpropyl]hexanamide
- N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N-[4-(hydroxymethyl)phenyl]-L-alaninamide
- CAS:
- 1870916-87-2
- MF:
- C25H34N4O6
- MW:
- 486.56
- Product Categories:
-
- Linker
- ADC LINKER
- Mol File:
- 1870916-87-2.mol
Mc-Val-Ala-PAB Chemical Properties
- Boiling point:
- 828.6±65.0 °C(Predicted)
- Density
- 1.249±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO: Sparingly soluble: 1-10 mg/ml
- form
- Solid
- pka
- 13.48±0.70(Predicted)
- color
- Off-white to yellow
- InChIKey
- BNBPKWDHHBIUIY-SBUREZEXSA-N
- SMILES
- C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(CO)C=C1
Mc-Val-Ala-PAB Usage And Synthesis
Uses
Mc- Val- Ala- PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
IC 50
Protease Cleavable Linker; Cleavable Linker
References
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] DAPENG LI . AGCM-22, a novel cetuximab-based EGFR-targeting antibody-drug-conjugate with highly selective anti-glioblastoma efficacy[J]. Bioorganic & Medicinal Chemistry, 2024, 102: Article 117657. DOI: 10.1016/j.bmc.2024.117657
[3] SHIYONG FAN . Novel antibody-antibiotic conjugate using KRM-1657 as payload eliminates intracellular MRSA in vitro and in vivo[J]. Bioorganic Chemistry, 2024, 150: Article 107532. DOI: 10.1016/j.bioorg.2024.107532
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