IDF-11774
IDF-11774 Basic information
- Product Name:
- IDF-11774
- Synonyms:
-
- IDF-11774
- Ethanone, 1-(4-methyl-1-piperazinyl)-2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)-
- IDF 11774;IDF11774
- CS-2820
- IDF 11774,inhibit,HIF-PH,IDF-11774,Hypoxia-inducible factors,HIFs,IDF11774,Inhibitor,HIF/HIF Prolyl-Hydroxylase
- 2-[4-(1-adamantyl)phenoxy]-1-(4-methylpiperazin-1-yl)ethanone
- 2-(4-(Adamantan-1-yl)phenoxy)-1-(4-methylpiperazin-1-yl)ethanone
- IDF-11774, 10 mM in DMSO
- CAS:
- 1429054-28-3
- MF:
- C23H32N2O2
- MW:
- 368.51
- Mol File:
- 1429054-28-3.mol
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IDF-11774 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO : 60 mg/mL (162.82 mM)
- form
- Solid
- color
- White to off-white
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IDF-11774 Usage And Synthesis
Uses
IDF-11774, is a novel hypoxia-inducible factor (HIF)-1 inhibitor with an IC50 of 3.65 μM in cancer cell line. It has shown to reduce capillary network formation on Matrigel, when human umbilical vascular endothelial cells (HUVECs) were treated with IDF-11774.
in vivo
Luciferase activity and HIF-1α accumulation are strongly suppressed in the tumors of mice treated by oral administration of IDF-11774, compare with the control. When IDF-11774 is orally administered daily for two weeks, significant dose-dependent tumor regression is observed in the mouse model[1].
IDF-11774Supplier
Shanghai Raise Chemical Technology Co.,Ltd
- Tel
- 15026594951
- rs@raise-chem.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghaizehan biopharma technology co., Ltd.
- Tel
- 021-61350663 13052117465
- sales@zehanbiopharma.com
Shanghai Beckham Medical Technology Co., Ltd
- Tel
- 13816613772
- huahero21@sina.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com