CL2-SN38
CL2-SN38 Basic information
- Product Name:
- CL2-SN38
- Synonyms:
-
- CL2-SN38
- CS-2807
- L-Lysinamide, N-[32-[4-[[[[4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexyl]carbonyl]amino]methyl]-1H-1,2,3-triazol-1-yl]-1,5-dioxo-3,9,12,15,18,21,24,27,30-nonaoxa-6-azadotriacont-1-yl]-L-phenylalanyl-N-[4-[[[[[(4S)-4,11-diethyl-3,4,12,14-tetrahydro-9-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,...
- CL2-SN-38(DCA)
- CAS:
- 1036969-20-6
- MF:
- C82H106N12O23
- MW:
- 1627.81
- Product Categories:
-
- ADC LINKER
- Mol File:
- 1036969-20-6.mol
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CL2-SN38 Chemical Properties
- Density
- 1.38±0.1 g/cm3(Predicted)
- solubility
- DMSO: >1 mg/ml
Ethanol: >1 mg/ml - pka
- 9.12±0.40(Predicted)
- form
- Solid
- color
- Light yellow to green yellow
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CL2-SN38 Usage And Synthesis
Uses
CL2-SN-38 is a cleavable linker-based agent-Linker conjugate, it can conjugate with the anti-Trop-2-humanized antibody hRS7. CL2-SN-38 can be used for the reasearch of cancer[1].
IC 50
Camptothecins
References
[1] Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69. DOI:10.1158/1078-0432.CCR-10-2939
[2] SUNG-JU MOON. Antibody Conjugates of 7-Ethyl-10-hydroxycamptothecin (SN-38) for Targeted Cancer Chemotherapy[J]. Journal of Medicinal Chemistry, 2008, 51 21: 6916-6926. DOI: 10.1021/jm800719t
CL2-SN38Supplier
Shanghai Chaolan Chemical Technology Center
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- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com
Shanghai Hongye Biotechnology Co. Ltd
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- 400-9205774
- sales@glpbio.cn
Fan De(Beijing) Biotechnology Co., Ltd.
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- 15911056312
- liming@bio-fount.com
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
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- 18081075745
- chemflowtech@sina.com
TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
- marketing@targetmol.com