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AZTSBAWJROLRIQ-LESCRADOSA-N

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AZTSBAWJROLRIQ-LESCRADOSA-N Basic information

Product Name:
AZTSBAWJROLRIQ-LESCRADOSA-N
Synonyms:
  • AZTSBAWJROLRIQ-LESCRADOSA-N
  • (3R,4S,5S)-tert-Butyl 4-(((benzyloxy)carbonyl)amino)-3-hydroxy-5-methylheptanoate
  • Heptanoic acid, 3-hydroxy-5-methyl-4-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, [3R-(3R*,4S*,5S*)]- (9CI)
  • tert-butyl (3R,4S,5S)-4-(((benzyloxy)carbonyl)amino)-3-hydroxy-5-methylheptanoate
  • tert-butyl (3R,4S,5S)-3-hydroxy-5-methyl-4-(phenylmethoxycarbonylamino)heptanoate
  • Monomethyl auristatin E intermediate-7
CAS:
135383-55-0
MF:
C20H31NO5
MW:
365.46
Mol File:
135383-55-0.mol
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AZTSBAWJROLRIQ-LESCRADOSA-N Chemical Properties

form 
Solid
color 
White to off-white
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AZTSBAWJROLRIQ-LESCRADOSA-N Usage And Synthesis

Uses

Monomethyl auristatin E intermediate-7 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].

References

[1] Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87. DOI:10.1158/0008-5472.CAN-14-1931

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