ChemicalBook > Product Catalog > Organic Chemistry > Carboxylic acids and derivatives > Carboxylic acid esters and derivatives > AZTSBAWJROLRIQ-LESCRADOSA-N
AZTSBAWJROLRIQ-LESCRADOSA-N
AZTSBAWJROLRIQ-LESCRADOSA-N Basic information
- Product Name:
- AZTSBAWJROLRIQ-LESCRADOSA-N
- Synonyms:
-
- AZTSBAWJROLRIQ-LESCRADOSA-N
- (3R,4S,5S)-tert-Butyl 4-(((benzyloxy)carbonyl)amino)-3-hydroxy-5-methylheptanoate
- Heptanoic acid, 3-hydroxy-5-methyl-4-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, [3R-(3R*,4S*,5S*)]- (9CI)
- tert-butyl (3R,4S,5S)-4-(((benzyloxy)carbonyl)amino)-3-hydroxy-5-methylheptanoate
- tert-butyl (3R,4S,5S)-3-hydroxy-5-methyl-4-(phenylmethoxycarbonylamino)heptanoate
- Monomethyl auristatin E intermediate-7
- CAS:
- 135383-55-0
- MF:
- C20H31NO5
- MW:
- 365.46
- Mol File:
- 135383-55-0.mol
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AZTSBAWJROLRIQ-LESCRADOSA-N Chemical Properties
- form
- Solid
- color
- White to off-white
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AZTSBAWJROLRIQ-LESCRADOSA-N Usage And Synthesis
Uses
Monomethyl auristatin E intermediate-7 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
References
[1] Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87. DOI:10.1158/0008-5472.CAN-14-1931
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