H-ARG-GLN-OH HYDROCHLORIDE SALT
H-ARG-GLN-OH HYDROCHLORIDE SALT Basic information
- Product Name:
- H-ARG-GLN-OH HYDROCHLORIDE SALT
- Synonyms:
-
- H-ARG-GLN-OH HCL
- H-ARG-GLN-OH HYDROCHLORIDE SALT
- H-Arg-Gln-OH
- L-Glutamine, L-arginyl-
- (S)-5-Amino-2-((S)-2-amino-5-guanidinopentanamido)-5-oxopentanoic acid
- Arg-Gln
- Arginyl-Glutamine
- CAS:
- 2483-17-2
- MF:
- C11H22N6O4
- MW:
- 302.33
- Mol File:
- 2483-17-2.mol
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H-ARG-GLN-OH HYDROCHLORIDE SALT Chemical Properties
- storage temp.
- -15°C
- Sequence
- Arg-Gln
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H-ARG-GLN-OH HYDROCHLORIDE SALT Usage And Synthesis
Uses
Arginyl-Glutamine is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy[1].
Definition
ChEBI: Arg-Gln is a dipeptide formed from L-arginyl and L-glutamine residues. It has a role as a metabolite.
in vivo
Arginyl-Glutamine (1-5 g/kg/day as a hydrochloride salt; i.p.; twice daily) dramatically inhibits retinal neovascularization in the mouse oxygen-induced retinopathy (OIR) model[1].
| Animal Model: | C57BL6/J mouse pups, oxygen-induced retinopathy (OIR) model[1] |
| Dosage: | 1.0, 2.5, or 5 g/kg per day |
| Administration: | Intraperitoneal injection, twice daily |
| Result: | Significantly decreased preretinal nuclei. Reduced neovascular tufts and vascular leakage in retinal vessels. Reduced preretinal neovascularization by 82% ± 7% and reduced VEGF mRNA by 64% ± 9% at 5 g/kg per day. |
References
[1] Neu J, et al. The dipeptide Arg-Gln inhibits retinal neovascularization in the mouse model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3151-5. DOI:10.1167/iovs.05-1473
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