GGTI-298
GGTI-298 Basic information
- Product Name:
- GGTI-298
- Synonyms:
-
- GGTI-298
- N-[[4-(2-(R)-AMINO-3-MERCAPTOPROPYL)AMINO]-2-NAPHTHYLBENZOYL]LEUCINE METHYL ESTER TRIFLUOROACETATE SALT
- N-4-[2(R)-AMINO-3-MERCAPTOPROPYL]AMINO-2-NAPHTHYLBENZOYL-(L)-LEUCINE METHYL ESTER, TFA
- GGTI-298 trifluoroacetate salt
- N-[[4-(2-(R)-Amino-3-mercaptopropyl)amino]-2-naphthylbenzoyl]leucine methyl ester trifluoroacetate salt
- N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucinemethylestertrifluoroacetatesalt
- GGTI298 (CF3CO2H)salt
- CS-2228
- CAS:
- 180977-44-0
- MF:
- C27H33N3O3S
- MW:
- 479.63
- EINECS:
- 604-604-1
- Product Categories:
-
- A cell-permeable, prodrug form of the GGTase I inhibitor GGTI-297.
- Mol File:
- Mol File
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GGTI-298 Chemical Properties
- Melting point:
- 99.5-100 °C
- Boiling point:
- 673.7±55.0 °C(Predicted)
- Density
- 1.190±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO: 22 mg/mL
- form
- solid
- pka
- 9.83±0.10(Predicted)
- color
- off-white
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MSDS
- Language:English Provider:SigmaAldrich
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GGTI-298 Usage And Synthesis
Uses
GGTI 298 is a CAAX peptidomimetic that selectively inhibits geranylgeranyltransferase I (GGTase I). It has been shown to arrest human tumor cells and induce apoptosis.
Definition
ChEBI: (2S)-2-[[[4-[[(2R)-2-amino-3-mercaptopropyl]amino]-2-(1-naphthalenyl)phenyl]-oxomethyl]amino]-4-methylpentanoic acid methyl ester is a leucine derivative.
GGTI-298Supplier
3B Pharmachem (Wuhan) International Co.,Ltd.
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Sigma-Aldrich
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