GSK-J2 (sodium salt) Chemical Properties

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

A crystalline solid

GSK-J2 (sodium salt) Usage And Synthesis

Description

The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer.^1,2 GSK-J2 is a pyridine regio-isomer of GSK-J1 which poorly inhibits JMJD3 (IC₅₀ > 100 μM), making it an appropriate negative control for in vitro studies involving GSK-J1.³ For in vivo research, cell-permeable prodrug forms of GSK-J1 and GSK-J2 are available as GSK-J4 and GSK-J5 , respectively. See the Structural Genomics Consortium (SGC) website for more information.

References

1. Agger, K., Cloos, P.A.C., Christensen, J., et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development Nature 449(7163),731-734(2011).
2. Hübner, M.R., and Spector, D.L. Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation Cold Spring Harb. Symp. Quant. Biol. 75,43-49(2010).
3. Kruidenier, L., Chung, C.W., Cheng, Z., et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response Nature 488,404-408(2012).