PF-05231023
PF-05231023 Basic information
- Product Name:
- PF-05231023
- Synonyms:
-
- PF-05231023
- PF 5231023
- PF-05231023; PF05231023; PF 05231023; PF-5231023; PF5231023; PF 5231023
- PF5231023
- PF-5231023
- 1H-Pyrrole-1-propanamide, 2,5-dihydro-2,5-dioxo-N-[2-[2-[3-oxo-3-[[4-[3-oxo-3-(2-oxo-1-azetidinyl)propyl]phenyl]amino]propoxy]ethoxy]ethyl]-
- Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD
- Mal-amido-PEG-2-C2-amido-Ph-C2-CO-AZD,PROTAC Linkers,MalamidoPEG2C2amidoPhC2COAZD,Inhibitor,Mal amido PEG2 C2 amido Ph C2 CO AZD,inhibit
- CAS:
- 1037589-69-7
- MF:
- C26H32N4O8
- MW:
- 528.55
- Mol File:
- 1037589-69-7.mol
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PF-05231023 Chemical Properties
- Boiling point:
- 849.9±65.0 °C(Predicted)
- Density
- 1.345±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml
- form
- A solid
- pka
- 14.34±0.70(Predicted)
- color
- White to off-white
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PF-05231023 Usage And Synthesis
Uses
Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (Mal-PEG2-AZD) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
in vivo
| Animal Model: | Eight week old Zucker rats[3] |
| Dosage: | 3?mg/kg and 10?mg/kg |
| Administration: | Subcutaneously twice a week for two weeks |
| Result: | There was no change of BW observed, and food intake was not changed in the treated groups compared to control. Caused a significant decrease of glucose excursion during the oral glucose tolerance test (OGTT) compared to control. |
| Animal Model: | 7-to-8-month-old Akita mice with type 1 diabete model[4] |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneally injected; twice a week; for four weeks |
| Result: | Administration improved retinal function in diabetic Akita mice. |
IC 50
PEGs
References
[1] Sonoda J, et al. FGF21-receptor agonists: an emerging therapeutic class for obesity-related diseases. Horm Mol Biol Clin Investig. 2017 May 19;30(2). DOI:10.1515/hmbci-2017-0002
PF-05231023Supplier
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
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- 17702719238 18971495150;
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ShangHai Caerulum Pharma Discovery Co., Ltd.
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- 18149758185
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Shanghai EFE Biological Technology Co., Ltd.
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- 021-65675885 18964387627
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ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
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Beijing Jin Ming Biotechnology Co., Ltd.
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- 010-60605840 18892239720
- psaitong@jm-bio.com