AurkinA
AurkinA Basic information
- Product Name:
- AurkinA
- Synonyms:
-
- AurkinA
- 4-Quinolinecarboxylic acid, 2-(3-bromophenyl)-8-fluoro-
- 2-(3-Bromophenyl)-8-fluoro-4-quinolinecarboxylicacid
- CAS:
- 1534060-58-6
- MF:
- C16H9BrFNO2
- MW:
- 346.15
- Mol File:
- 1534060-58-6.mol
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AurkinA Chemical Properties
- Boiling point:
- 490.6±45.0 °C(Predicted)
- Density
- 1.610±0.06 g/cm3(Predicted)
- pka
- 2.12±0.10(Predicted)
- form
- Solid
- color
- Light yellow to yellow
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AurkinA Usage And Synthesis
Uses
Aurkin A is an allosteric inhibitor for the interaction between Aurora A Kinase (also known also Aurka) and TPX2, through targeting the TPX2 binding sites with Kd of 3.77 μM [1].
IC 50
Aurora A: 3.77 μM (Kd)
References
[1] Janeek M, et al., Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2. Sci Rep. 2016 Jun 24;6:28528. DOI:10.1038/srep28528