MA-0204 Chemical Properties

Boiling point:

611.9±65.0 °C(Predicted)

Density 

1.23±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

Solid

pka

4.76±0.10(Predicted)

color 

White to off-white

MA-0204 Usage And Synthesis

Uses

MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD)[1].

in vivo

IC 50

PPARδ: 0.4 nM (EC₅₀, in human); PPARδ: 7.9 nM (EC₅₀, in mouse); PPARδ: 10 nM (EC₅₀, in rat)

References

[1] Lagu B, et al. Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD). ACS Med Chem Lett. 2018 Jul 31;9(9):935-940. DOI:10.1021/acsmedchemlett.8b00287