ORY-1001(trans)
ORY-1001(trans) Basic information
- Product Name:
- ORY-1001(trans)
- Synonyms:
-
- ORY-1001(trans)
- trans-N1-((1R,2S)-2-Phenylcyclopropyl)cyclohexane-1,4-diamine dihydrochloride
- Ladademstat
- ORY-1001 dihydrochloride
- Iadademstat dihydrochloride
- RO 7051790,RG 6016,Iadademstat dihydrochloride,Histone Demethylase,Iadademstat,RO7051790,inhibit,RG6016,Inhibitor,ORY1001,RO-7051790,ORY 1001,ORY-1001,RG-6016
- (1r,4R)-N1-((1R,2S)-2-phenylcyclopropyl)cyclohexane-1,4-diamine
- ORY-1001(Ladademstat)
- CAS:
- 1431303-72-8
- MF:
- C15H23ClN2
- MW:
- 266.81
- Mol File:
- 1431303-72-8.mol
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ORY-1001(trans) Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Water: 57.75 mg/mL (190.42 mM and warming); DMSO: 0.69 mg/mL (2.28 mM and warming)
- form
- Solid
- color
- White to off-white
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ORY-1001(trans) Usage And Synthesis
Uses
Iadademstat (ORY-1001) dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor.
in vivo
Iadademstat reduces AML tumor growth in mice and rat xenografts and increases survival time in a disseminated model of T-ALL[1].
References
[1] Maes T, et al. KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease. Epigenomics. 2015;7(4):609-26. doi: 10.2217/epi.15.9. DOI:10.2217/epi.15.9
[2] Tamara Maes, et al. ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia. Cancer Cell. 2018 Mar 12;33(3):495-511.e12. DOI:10.1016/j.ccell.2018.02.002
ORY-1001(trans)Supplier
Sichuan Wei Keqi Biological Technology Co., Ltd.
- Tel
- 028-81700200 18116577057
- 3003855609@qq.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
Beijing Solarbio Science & Tecnology Co., Ltd.
- Tel
- 010-50973130 18101056239
- 3193328036@qq.com
Jiaxing Deyi Chemical Co., Ltd.
- Tel
- 86-0573-85866609 13325730825
- 945717149@qq.com