CX-157
CX-157 Basic information
- Product Name:
- CX-157
- Synonyms:
-
- CX-157
- Phenoxathiin, 3-fluoro-7-(2,2,2-trifluoroethoxy)-, 10,10-dioxide
- CX 157,CX157
- 3-Fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiine 10,10-dioxide
- CAS:
- 205187-53-7
- MF:
- C14H8F4O4S
- MW:
- 348.27
- Mol File:
- 205187-53-7.mol
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CX-157 Chemical Properties
- Boiling point:
- 430.0±45.0 °C(Predicted)
- Density
- 1.549±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
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CX-157 Usage And Synthesis
Uses
CX-157 is a reversible inhibitor of monoamine oxidase-A (MAO-A) with an EC50 of 19.3 ng/mL.
in vivo
CX-157 is a reversible inhibitor of monoamine oxidase-A (MAO-A) with an EC50 of 19.3 ng/mL. CX-157 is an investigational compound currently in development for the treatment of major depressive disorder (MDD). Mechanistic studies in animals have shown that CX-157 acts to inhibit MAO-A activity in a reversible and competitive manner, elevating brain levels of monoamine neurotransmitters[1].
References
[1] Fowler JS, et al. Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157. Neuropsychopharmacology. 2010 Feb;35(3):623-31. DOI:10.1038/npp.2009.167
CX-157Supplier
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
Beijing Jin Ming Biotechnology Co., Ltd.
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
TargetMol Chemicals Inc.
- Tel
- 4008200310
- marketing@tsbiochem.com
Suzhou Meishi Biotechnology Co., Ltd.
- Tel
- 1173954148q
- meishipharma@126.com
Shanghai Yifei Biotechnology Co. , Ltd.
- Tel
- 021-65675885 18964387627
- customer_service@efebio.com