L 888607
L 888607 Basic information
- Product Name:
- L 888607
- Synonyms:
-
- L 888607
- 1H-Pyrrolo[1,2-a]indole-1-acetic acid, 9-[(4-chlorophenyl)thio]-6-fluoro-2,3-dihydro-, (1S)-
- CAS:
- 860033-06-3
- MF:
- C19H15ClFNO2S
- MW:
- 375.84
- Mol File:
- 860033-06-3.mol
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L 888607 Chemical Properties
- Boiling point:
- 583.8±50.0 °C(Predicted)
- Density
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 150 mg/mL (399.11 mM);Water : < 0.1 mg/mL (insoluble)
- form
- Solid
- pka
- 4.53±0.10(Predicted)
- color
- Light yellow to yellow
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L 888607 Usage And Synthesis
Uses
L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 has high affinity for the human CRTH2 receptor with a Ki value of 4 nM. L 888607 can be used for the research of several physiological events and metabolite[1].
in vivo
L 888607 (i.v., 5 mg/kg, single or oral, 20 mg/kg, single) shows relative stability in vivo[1].
| Animal Model: | Male (ICR)BR mice[1] |
| Dosage: | 5 mg/kg, 20 mg/kg |
| Administration: | i.v., 5 mg/kg, single or oral, 20 mg/kg, single |
| Result: | Showed no obvious side effect. |
IC 50
DP: 0.8 nM (Ki); TP Receptor: 283 nM (Ki); FP Receptor: 10018 nM (Ki); IP Receptor: 14434 nM (Ki)
References
[1] Gervais FG, Identification of a potent and selective synthetic agonist at the CRTH2 receptor. Mol Pharmacol. 2005 Jun;67(6):1834-9. DOI:10.1124/mol.104.009068
L 888607Supplier
Fan De(Beijing) Biotechnology Co., Ltd.
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- 15911056312
- liming@bio-fount.com
TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
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Beijing xinyanhui pharmaceutical research and development co., LTD
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- 13969155946
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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- 18818260767
- sales@chemegen.com
Shanghai hongqu biomedical technology co. LTD
- Tel
- 88888888888
- hongquchem@qq.com