N-(2-amino-5-(thiophen-2-yl)phenyl)-2-(piperazin-1-yl)quinoline-6-carboxamide Chemical Properties

Boiling point:

602.7±55.0 °C(Predicted)

Density 

1.338±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : 83.33 mg/mL (194.00 mM)

form 

Solid

pka

12.18±0.70(Predicted)

color 

Light yellow to yellow

N-(2-amino-5-(thiophen-2-yl)phenyl)-2-(piperazin-1-yl)quinoline-6-carboxamide Usage And Synthesis

Uses

ACY-??957 is an orally selective inhibitor of HDAC1 and HDAC2 which may be useful in treatment of diseases such as cancer, HIV and sickle-cell anemia.

IC 50

HDAC1: 7 nM (IC₅₀); HDAC2: 18 nM (IC₅₀); HDAC3: 1300 nM (IC₅₀)