Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL Chemical Properties

Boiling point:

522.5±50.0 °C(Predicted)

Density 

1.214±0.06 g/cm3(Predicted)

storage temp. 

-15°C

pka

-1.00±0.40(Predicted)

Sequence

Pro-{Pro-Aldehyde-dimethyl acetal}

Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL Usage And Synthesis

Uses

Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC50= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease[1][2].

IC 50

PREP: 12 nM (IC₅₀)

References

[1] Robin S B Williams, et al. A common mechanism of action for three mood-stabilizing drugs. Nature. 2002 May 16;417(6886):292-5. DOI:10.1038/417292a
[2] Andis Klegeris, et al. Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial?and?THP‐1 cell neurotoxicity. Glia. 2008 Apr 15;56(6):675-85. DOI:10.1002/glia.20645

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