PKC-theta inhibitor Chemical Properties

Boiling point:

597.1±60.0 °C(Predicted)

Density 

1.356±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : 62.5 mg/mL (137.53 mM)

form 

Solid

pka

10.27±0.29(Predicted)

color 

White to off-white

PKC-theta inhibitor Usage And Synthesis

Uses

PKC-theta inhibitor 2 is a potent and selective PKC-θ inhibitor with an IC50 value of 18 nM[1].

IC 50

PKCθ: 18 nM (IC₅₀)

References

[1] Cywin CL, et al. Discovery of potent and selective PKC-theta inhibitors. Bioorg Med Chem Lett. 2007 Jan 1;17(1):225-30. DOI:10.1016/j.bmcl.2006.09.056