Fmoc-Val-Ala-pAB-PNP
Fmoc-Val-Ala-pAB-PNP Basic information
- Product Name:
- Fmoc-Val-Ala-pAB-PNP
- Synonyms:
-
- Fmoc-Val-Ala-pAB-PNP
- L-Alaninamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
- Fmoc-Val-Ala-pAB-PNP USP/EP/BP
- (9H-Fluoren-9-yl)methyl ((S)-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate
- 4-[(S)-2-[(S)-2-(Fmoc-amino)-3-methylbutanamido]propanamido]benzyl (4-Nitrophenyl) Carbonate
- CAS:
- 1394238-92-6
- MF:
- C37H36N4O9
- MW:
- 680.7
- Product Categories:
-
- ADC LINKER
- Linker
- ADCs Linkers
- Mol File:
- 1394238-92-6.mol
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Fmoc-Val-Ala-pAB-PNP Chemical Properties
- Boiling point:
- 931.4±65.0 °C(Predicted)
- Density
- 1.322±0.06 g/cm3(Predicted)
- pka
- 10.63±0.46(Predicted)
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Fmoc-Val-Ala-pAB-PNP Usage And Synthesis
Uses
Fmoc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
In vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Description
Fmoc-Val-Ala-PAB-PNP can be used to design cleavable ADC linkers. The Val-Ala, as shown in the ACD Zynlonta, is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations.
Fmoc-Val-Ala-pAB-PNPSupplier
Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd. Gold
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- 13414494621
- chenchao02lzu@126.com
Shanghai Topbiochem Technology Co., Ltd
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- 021-58170097
- info@topbiochem.com
Tianjin Chempharmatech Co.,Ltd.
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- 022-66211079 13212288319
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Hygeia (Chengdu) pharmaceutical technique Co., Ltd
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- 028-84502008 13568869383
- sales@hygeiapharm.com
Finetech Industry Limited
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- 027-87465837 19945049750
- sales@finetechnology-ind.com